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The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.
Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT. Gutierrez A, et al. Among authors: kentsis a. Blood. 2011 Oct 13;118(15):4169-73. doi: 10.1182/blood-2010-11-318873. Epub 2011 Aug 30. Blood. 2011. PMID: 21878675 Free PMC article. Clinical Trial.
Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.
Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look AT. Mansour MR, et al. Among authors: kentsis a. Br J Haematol. 2015 Jan;168(2):230-8. doi: 10.1111/bjh.13115. Epub 2014 Sep 26. Br J Haematol. 2015. PMID: 25256574 Free PMC article.
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, Vande Woude G, Licht JD, Kung AL, Staudt LM, Look AT. Kentsis A, et al. Nat Med. 2012 Jul;18(7):1118-22. doi: 10.1038/nm.2819. Nat Med. 2012. PMID: 22683780 Free PMC article.
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A. Etchin J, et al. Among authors: kentsis a. Br J Haematol. 2013 Apr;161(1):117-27. doi: 10.1111/bjh.12231. Epub 2013 Feb 4. Br J Haematol. 2013. PMID: 23373539 Free PMC article.
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.
Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, Look AT. Etchin J, et al. Among authors: kentsis a. Leukemia. 2013 Jan;27(1):66-74. doi: 10.1038/leu.2012.219. Epub 2012 Jul 31. Leukemia. 2013. PMID: 22847027 Free PMC article.
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.
Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC. Gutierrez A, et al. Among authors: kentsis a. J Clin Invest. 2014 Feb;124(2):644-55. doi: 10.1172/JCI65093. Epub 2014 Jan 9. J Clin Invest. 2014. PMID: 24401270 Free PMC article.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML.
Heikamp EB, Henrich JA, Perner F, Wong EM, Hatton C, Wen Y, Barwe SP, Gopalakrishnapillai A, Xu H, Uckelmann HJ, Takao S, Kazansky Y, Pikman Y, McGeehan GM, Kolb EA, Kentsis A, Armstrong SA. Heikamp EB, et al. Among authors: kentsis a. Blood. 2022 Feb 10;139(6):894-906. doi: 10.1182/blood.2021012806. Blood. 2022. PMID: 34582559 Free PMC article.
117 results