Groudine M - Search Results

1

A functional element necessary for fetal hemoglobin silencing.

Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. Sankaran VG, et al. Among authors: groudine m. N Engl J Med. 2011 Sep 1;365(9):807-14. doi: 10.1056/NEJMoa1103070. N Engl J Med. 2011. PMID: 21879898 Free PMC article.

2

Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription.

Bender MA, Byron R, Ragoczy T, Telling A, Bulger M, Groudine M. Bender MA, et al. Among authors: groudine m. Blood. 2006 Aug 15;108(4):1395-401. doi: 10.1182/blood-2006-04-014431. Epub 2006 Apr 27. Blood. 2006. PMID: 16645164 Free PMC article.

3

Developmental and species-divergent globin switching are driven by BCL11A.

Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Sankaran VG, et al. Among authors: groudine m. Nature. 2009 Aug 27;460(7259):1093-7. doi: 10.1038/nature08243. Epub 2009 Aug 5. Nature. 2009. PMID: 19657335 Free PMC article.

4

Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region.

Bender MA, Bulger M, Close J, Groudine M. Bender MA, et al. Among authors: groudine m. Mol Cell. 2000 Feb;5(2):387-93. doi: 10.1016/s1097-2765(00)80433-5. Mol Cell. 2000. PMID: 10882079 Free article.

5

The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation.

Bender MA, Ragoczy T, Lee J, Byron R, Telling A, Dean A, Groudine M. Bender MA, et al. Among authors: groudine m. Blood. 2012 Apr 19;119(16):3820-7. doi: 10.1182/blood-2011-09-380485. Epub 2012 Feb 29. Blood. 2012. PMID: 22378846 Free PMC article.

6

The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.

Schübeler D, Groudine M, Bender MA. Schübeler D, et al. Among authors: groudine m. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11432-7. doi: 10.1073/pnas.201394698. Epub 2001 Sep 11. Proc Natl Acad Sci U S A. 2001. PMID: 11553791 Free PMC article.

7

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, Neri F, Diegel M, Giste E, Haugen E, Dunn D, Wilken MS, Josefowicz S, Samstein R, Chang KH, Eichler EE, De Bruijn M, Reh TA, Skoultchi A, Rudensky A, Orkin SH, Papayannopoulou T, Treuting PM, Selleri L, Kaul R, Groudine M, Bender MA, Stamatoyannopoulos JA. Vierstra J, et al. Among authors: groudine m. Science. 2014 Nov 21;346(6212):1007-12. doi: 10.1126/science.1246426. Science. 2014. PMID: 25411453 Free PMC article.

8

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.

Hu X, Bulger M, Bender MA, Fields J, Groudine M, Fiering S. Hu X, et al. Among authors: groudine m. Blood. 2006 Jan 15;107(2):821-6. doi: 10.1182/blood-2005-06-2308. Epub 2005 Sep 27. Blood. 2006. PMID: 16189270 Free PMC article.

9

Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.

Fromm G, de Vries C, Byron R, Fields J, Fiering S, Groudine M, Bender MA, Palis J, Bulger M. Fromm G, et al. Among authors: groudine m. Blood. 2009 Oct 15;114(16):3479-88. doi: 10.1182/blood-2009-03-210690. Epub 2009 Aug 18. Blood. 2009. PMID: 19690338 Free PMC article.

10

The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.

Sawado T, Halow J, Bender MA, Groudine M. Sawado T, et al. Among authors: groudine m. Genes Dev. 2003 Apr 15;17(8):1009-18. doi: 10.1101/gad.1072303. Epub 2003 Apr 2. Genes Dev. 2003. PMID: 12672691 Free PMC article.

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