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Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Woon EC, et al. Among authors: hillringhaus l. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi: 10.1002/anie.201107833. Epub 2012 Jan 12. Angew Chem Int Ed Engl. 2012. PMID: 22241642 No abstract available.
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A. Chowdhury R, et al. Among authors: hillringhaus l. EMBO Rep. 2011 May;12(5):463-9. doi: 10.1038/embor.2011.43. Epub 2011 Apr 1. EMBO Rep. 2011. PMID: 21460794 Free PMC article.
Sensitization of Tumors for Attack by Virus-Specific CD8+ T-Cells Through Antibody-Mediated Delivery of Immunogenic T-Cell Epitopes.
Sefrin JP, Hillringhaus L, Mundigl O, Mann K, Ziegler-Landesberger D, Seul H, Tabares G, Knoblauch D, Leinenbach A, Friligou I, Dziadek S, Offringa R, Lifke V, Lifke A. Sefrin JP, et al. Among authors: hillringhaus l. Front Immunol. 2019 Aug 21;10:1962. doi: 10.3389/fimmu.2019.01962. eCollection 2019. Front Immunol. 2019. PMID: 31555260 Free PMC article.
Elecsys® Total-Tau and Phospho-Tau (181P) CSF assays: Analytical performance of the novel, fully automated immunoassays for quantification of tau proteins in human cerebrospinal fluid.
Lifke V, Kollmorgen G, Manuilova E, Oelschlaegel T, Hillringhaus L, Widmann M, von Arnim CAF, Otto M, Christenson RH, Powers JL, Shaw LM, Hansson O, Doecke JD, Li QX, Teunissen C, Tumani H, Blennow K. Lifke V, et al. Among authors: hillringhaus l. Clin Biochem. 2019 Oct;72:30-38. doi: 10.1016/j.clinbiochem.2019.05.005. Epub 2019 May 23. Clin Biochem. 2019. PMID: 31129184 Free article.