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Free insulin-like growth factor binding protein-3 (IGFBP-3) reduces retinal vascular permeability in association with a reduction of acid sphingomyelinase (ASMase).
Kielczewski JL, Li Calzi S, Shaw LC, Cai J, Qi X, Ruan Q, Wu L, Liu L, Hu P, Chan-Ling T, Mames RN, Firth S, Baxter RC, Turowski P, Busik JV, Boulton ME, Grant MB. Kielczewski JL, et al. Among authors: liu l. Invest Ophthalmol Vis Sci. 2011 Oct 21;52(11):8278-86. doi: 10.1167/iovs.11-8167. Invest Ophthalmol Vis Sci. 2011. PMID: 21931131 Free PMC article.
β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, Joussen AM, Boulton ME. Cai J, et al. Among authors: liu l. EMBO Mol Med. 2012 Sep;4(9):980-91. doi: 10.1002/emmm.201101084. Epub 2012 Aug 20. EMBO Mol Med. 2012. PMID: 22903875 Free PMC article.
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
Santulli RJ, Kinney WA, Ghosh S, Decorte BL, Liu L, Tuman RW, Zhou Z, Huebert N, Bursell SE, Clermont AC, Grant MB, Shaw LC, Mousa SA, Galemmo RA Jr, Johnson DL, Maryanoff BE, Damiano BP. Santulli RJ, et al. Among authors: liu l. J Pharmacol Exp Ther. 2008 Mar;324(3):894-901. doi: 10.1124/jpet.107.131656. Epub 2007 Dec 14. J Pharmacol Exp Ther. 2008. PMID: 18083913
IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.
Zhang Q, Jiang Y, Miller MJ, Peng B, Liu L, Soderland C, Tang J, Kern TS, Pintar J, Steinle JJ. Zhang Q, et al. Among authors: liu l. Invest Ophthalmol Vis Sci. 2013 Aug 9;54(8):5376-84. doi: 10.1167/iovs.13-12497. Invest Ophthalmol Vis Sci. 2013. PMID: 23868984 Free PMC article.
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