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Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease.
Hamamdzic D, Fenning RS, Patel D, Mohler ER 3rd, Orlova KA, Wright AC, Llano R, Keane MG, Shannon RP, Birnbaum MJ, Wilensky RL. Hamamdzic D, et al. Among authors: llano r. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H699-706. doi: 10.1152/ajpheart.00071.2010. Epub 2010 Jul 2. Am J Physiol Heart Circ Physiol. 2010. PMID: 20601459 Free PMC article.
Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature.
Mohler ER 3rd, Sarov-Blat L, Shi Y, Hamamdzic D, Zalewski A, Macphee C, Llano R, Pelchovitz D, Mainigi SK, Osman H, Hallman T, Steplewski K, Gertz Z, Lu MM, Wilensky RL. Mohler ER 3rd, et al. Among authors: llano r. Arterioscler Thromb Vasc Biol. 2008 May;28(5):850-5. doi: 10.1161/ATVBAHA.107.154534. Epub 2008 Feb 14. Arterioscler Thromb Vasc Biol. 2008. PMID: 18276914