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DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta.
Novakovic B, Wong NC, Sibson M, Ng HK, Morley R, Manuelpillai U, Down T, Rakyan VK, Beck S, Hiendleder S, Roberts CT, Craig JM, Saffery R. Novakovic B, et al. J Biol Chem. 2010 Mar 26;285(13):9583-9593. doi: 10.1074/jbc.M109.064956. Epub 2010 Jan 13. J Biol Chem. 2010. PMID: 20071334 Free PMC article.
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).
Rakyan VK, Down TA, Thorne NP, Flicek P, Kulesha E, Gräf S, Tomazou EM, Bäckdahl L, Johnson N, Herberth M, Howe KL, Jackson DK, Miretti MM, Fiegler H, Marioni JC, Birney E, Hubbard TJ, Carter NP, Tavaré S, Beck S. Rakyan VK, et al. Among authors: down ta. Genome Res. 2008 Sep;18(9):1518-29. doi: 10.1101/gr.077479.108. Epub 2008 Jun 24. Genome Res. 2008. PMID: 18577705 Free PMC article.
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
Bell CG, Finer S, Lindgren CM, Wilson GA, Rakyan VK, Teschendorff AE, Akan P, Stupka E, Down TA, Prokopenko I, Morison IM, Mill J, Pidsley R; International Type 2 Diabetes 1q Consortium; Deloukas P, Frayling TM, Hattersley AT, McCarthy MI, Beck S, Hitman GA. Bell CG, et al. Among authors: down ta. PLoS One. 2010 Nov 18;5(11):e14040. doi: 10.1371/journal.pone.0014040. PLoS One. 2010. PMID: 21124985 Free PMC article.
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.
Feber A, Wilson GA, Zhang L, Presneau N, Idowu B, Down TA, Rakyan VK, Noon LA, Lloyd AC, Stupka E, Schiza V, Teschendorff AE, Schroth GP, Flanagan A, Beck S. Feber A, et al. Among authors: down ta. Genome Res. 2011 Apr;21(4):515-24. doi: 10.1101/gr.109678.110. Epub 2011 Feb 1. Genome Res. 2011. PMID: 21324880 Free PMC article.
70 results