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Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.
Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E. Urbano M, et al. Among authors: chase p. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6739-45. doi: 10.1016/j.bmcl.2011.09.049. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21982495 Free PMC article.
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).
Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P. Schröter T, et al. Among authors: chase p. J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806. J Biomol Screen. 2008. PMID: 18227223
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H. Schürer SC, et al. Among authors: chase p. ACS Chem Biol. 2008 Aug 15;3(8):486-98. doi: 10.1021/cb800051m. Epub 2008 Jul 1. ACS Chem Biol. 2008. PMID: 18590333 Free PMC article.
Small molecule activators of TRPML3.
Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S. Grimm C, et al. Among authors: chase p. Chem Biol. 2010 Feb 26;17(2):135-48. doi: 10.1016/j.chembiol.2009.12.016. Chem Biol. 2010. PMID: 20189104 Free PMC article.
455 results