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Antibacterial optimization of 4-aminothiazolyl analogues of the natural product GE2270 A: identification of the cycloalkylcarboxylic acids.
J Med Chem. 2011 Dec 8;54(23):8099-109. doi: 10.1021/jm200938f. Epub 2011 Nov 1.
J Med Chem. 2011.
PMID: 21999529
Discovery of LFF571: an investigational agent for Clostridium difficile infection.
LaMarche MJ, Leeds JA, Amaral A, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Ding J, Dzink-Fox J, Gamber G, Jain A, Lee K, Lee L, Lister T, McKenney D, Mullin S, Osborne C, Palestrant D, Patane MA, Rann EM, Sachdeva M, Shao J, Tiamfook S, Trzasko A, Whitehead L, Yifru A, Yu D, Yan W, Zhu Q.
LaMarche MJ, et al. Among authors: dewhurst jm.
J Med Chem. 2012 Mar 8;55(5):2376-87. doi: 10.1021/jm201685h. Epub 2012 Feb 23.
J Med Chem. 2012.
PMID: 22315981
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In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.
Leeds JA, LaMarche MJ, Brewer JT, Bushell SM, Deng G, Dewhurst JM, Dzink-Fox J, Gangl E, Jain A, Lee L, Lilly M, Manni K, Mullin S, Neckermann G, Osborne C, Palestrant D, Patane MA, Raimondi A, Ranjitkar S, Rann EM, Sachdeva M, Shao J, Tiamfook S, Whitehead L, Yu D.
Leeds JA, et al. Among authors: dewhurst jm.
Antimicrob Agents Chemother. 2011 Nov;55(11):5277-83. doi: 10.1128/AAC.00582-11. Epub 2011 Aug 8.
Antimicrob Agents Chemother. 2011.
PMID: 21825297
Free PMC article.
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Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV).
Bonavia A, Franti M, Pusateri Keaney E, Kuhen K, Seepersaud M, Radetich B, Shao J, Honda A, Dewhurst J, Balabanis K, Monroe J, Wolff K, Osborne C, Lanieri L, Hoffmaster K, Amin J, Markovits J, Broome M, Skuba E, Cornella-Taracido I, Joberty G, Bouwmeester T, Hamann L, Tallarico JA, Tommasi R, Compton T, Bushell SM.
Bonavia A, et al.
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6739-44. doi: 10.1073/pnas.1017142108. Epub 2011 Apr 18.
Proc Natl Acad Sci U S A. 2011.
PMID: 21502533
Free PMC article.
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Atomic-scale characterization of conformational changes in the preQ₁ riboswitch aptamer upon ligand binding.
Petrone PM, Dewhurst J, Tommasi R, Whitehead L, Pomerantz AK.
Petrone PM, et al.
J Mol Graph Model. 2011 Sep;30:179-85. doi: 10.1016/j.jmgm.2011.07.006. Epub 2011 Jul 22.
J Mol Graph Model. 2011.
PMID: 21831681
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AutoLock: a semiautomated system for radiotherapy treatment plan quality control.
Dewhurst JM, Lowe M, Hardy MJ, Boylan CJ, Whitehurst P, Rowbottom CG.
Dewhurst JM, et al.
J Appl Clin Med Phys. 2015 May 8;16(3):5396. doi: 10.1120/jacmp.v16i3.5396.
J Appl Clin Med Phys. 2015.
PMID: 26103498
Free PMC article.
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