Schuler W - Search Results

1

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

van Eis MJ, Evenou JP, Floersheim P, Gaul C, Cowan-Jacob SW, Monovich L, Rummel G, Schuler W, Stark W, Strauss A, von Matt A, Vangrevelinghe E, Wagner J, Soldermann N. van Eis MJ, et al. Among authors: schuler w. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7367-72. doi: 10.1016/j.bmcl.2011.10.025. Epub 2011 Oct 21. Bioorg Med Chem Lett. 2011. PMID: 22078216

2

Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.

van Eis MJ, Evenou J, Schuler W, Zenke G, Vangrevelinghe E, Wagner J, von Matt P. van Eis MJ, et al. Among authors: schuler w. Bioorg Med Chem Lett. 2017 Feb 15;27(4):781-786. doi: 10.1016/j.bmcl.2017.01.038. Epub 2017 Jan 16. Bioorg Med Chem Lett. 2017. PMID: 28131714

3

Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.

Shaw D, Hollingworth G, Soldermann N, Sprague E, Schuler W, Vangrevelinghe E, Duggan N, Thomas M, Kosaka T, Waters N, van Eis MJ. Shaw D, et al. Among authors: schuler w. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4812-7. doi: 10.1016/j.bmcl.2014.09.002. Epub 2014 Sep 6. Bioorg Med Chem Lett. 2014. PMID: 25248678

4

A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.

Hersperger R, Buchheit KH, Cammisuli S, Enz A, Lohse O, Ponelle M, Schuler W, Schweitzer A, Walker C, Zehender H, Zenke G, Zimmerlin AG, Zollinger M, Mazzoni L, Fozard JR. Hersperger R, et al. Among authors: schuler w. J Med Chem. 2004 Sep 23;47(20):4950-7. doi: 10.1021/jm031101l. J Med Chem. 2004. PMID: 15369399

5

Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity.

Sedrani R, Jones LH, Jutzi-Eme AM, Schuler W, Cottens S. Sedrani R, et al. Among authors: schuler w. Bioorg Med Chem Lett. 1999 Feb 8;9(3):459-62. doi: 10.1016/s0960-894x(99)00007-4. Bioorg Med Chem Lett. 1999. PMID: 10091702

6

Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.

Hersperger R, Schuler W, Zenke G. Hersperger R, et al. Among authors: schuler w. Bioorg Med Chem Lett. 1999 Jan 18;9(2):227-32. doi: 10.1016/s0960-894x(98)00702-1. Bioorg Med Chem Lett. 1999. PMID: 10021934

7

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas.

Naylor TL, Tang H, Ratsch BA, Enns A, Loo A, Chen L, Lenz P, Waters NJ, Schuler W, Dörken B, Yao YM, Warmuth M, Lenz G, Stegmeier F. Naylor TL, et al. Among authors: schuler w. Cancer Res. 2011 Apr 1;71(7):2643-53. doi: 10.1158/0008-5472.CAN-10-2525. Epub 2011 Feb 15. Cancer Res. 2011. PMID: 21324920

8

Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Schuler W, Bigaud M, Brinkmann V, Di Padova F, Geisse S, Gram H, Hungerford V, Kleuser B, Kristofic C, Menninger K, Tees R, Wieczorek G, Wilt C, Wioland C, Zurini M. Schuler W, et al. Transplantation. 2004 Mar 15;77(5):717-26. doi: 10.1097/01.tp.0000116563.72763.83. Transplantation. 2004. PMID: 15021835

9

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreier MH. Schuler W, et al. Transplantation. 1997 Jul 15;64(1):36-42. doi: 10.1097/00007890-199707150-00008. Transplantation. 1997. PMID: 9233698

10

Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action.

Zenke G, Strittmatter U, Fuchs S, Quesniaux VF, Brinkmann V, Schuler W, Zurini M, Enz A, Billich A, Sanglier JJ, Fehr T. Zenke G, et al. Among authors: schuler w. J Immunol. 2001 Jun 15;166(12):7165-71. doi: 10.4049/jimmunol.166.12.7165. J Immunol. 2001. PMID: 11390463

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