Wagner J - Search Results

1

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

van Eis MJ, Evenou JP, Floersheim P, Gaul C, Cowan-Jacob SW, Monovich L, Rummel G, Schuler W, Stark W, Strauss A, von Matt A, Vangrevelinghe E, Wagner J, Soldermann N. van Eis MJ, et al. Among authors: wagner j. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7367-72. doi: 10.1016/j.bmcl.2011.10.025. Epub 2011 Oct 21. Bioorg Med Chem Lett. 2011. PMID: 22078216

2

Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-α/β.

van Eis MJ, Evenou J, Schuler W, Zenke G, Vangrevelinghe E, Wagner J, von Matt P. van Eis MJ, et al. Among authors: wagner j. Bioorg Med Chem Lett. 2017 Feb 15;27(4):781-786. doi: 10.1016/j.bmcl.2017.01.038. Epub 2017 Jan 16. Bioorg Med Chem Lett. 2017. PMID: 28131714

3

Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.

Wagner J, Kallen J, Ehrhardt C, Evenou JP, Wagner D. Wagner J, et al. Among authors: wagner d. J Med Chem. 1998 Sep 10;41(19):3664-74. doi: 10.1021/jm981013e. J Med Chem. 1998. PMID: 9733491

4

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.

Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D. Betschart C, et al. Among authors: wagner j. J Med Chem. 2013 Oct 10;56(19):7590-607. doi: 10.1021/jm4007627. Epub 2013 Sep 18. J Med Chem. 2013. PMID: 23964859

5

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.

Carcache DA, Vulpetti A, Kallen J, Mattes H, Orain D, Stringer R, Vangrevelinghe E, Wolf RM, Kaupmann K, Ottl J, Dawson J, Cooke NG, Hoegenauer K, Billich A, Wagner J, Guntermann C, Hintermann S. Carcache DA, et al. Among authors: wagner j. J Med Chem. 2018 Aug 9;61(15):6724-6735. doi: 10.1021/acs.jmedchem.8b00529. Epub 2018 Jul 24. J Med Chem. 2018. PMID: 29990434

6

Synthesis of derivatives of the novel cyclophilin-binding immunosuppressant sanglifehrin A with reduced numbers of polar functions.

Bänteli R, Wagner J, Zenke G. Bänteli R, et al. Among authors: wagner j. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1609-12. doi: 10.1016/s0960-894x(01)00293-1. Bioorg Med Chem Lett. 2001. PMID: 11412991

7

Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution.

Kallen J, Sedrani R, Zenke G, Wagner J. Kallen J, et al. Among authors: wagner j. J Biol Chem. 2005 Jun 10;280(23):21965-71. doi: 10.1074/jbc.M501623200. Epub 2005 Mar 16. J Biol Chem. 2005. PMID: 15772070 Free article.

8

Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.

Hoegenauer K, Kallen J, Jiménez-Núñez E, Strang R, Ertl P, Cooke NG, Hintermann S, Voegtle M, Betschart C, McKay DJJ, Wagner J, Ottl J, Beerli C, Billich A, Dawson J, Kaupmann K, Streiff M, Gobeau N, Harlfinger S, Stringer R, Guntermann C. Hoegenauer K, et al. Among authors: wagner j. J Med Chem. 2019 Dec 12;62(23):10816-10832. doi: 10.1021/acs.jmedchem.9b01291. Epub 2019 Dec 3. J Med Chem. 2019. PMID: 31729873

9

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.

Hintermann S, Guntermann C, Mattes H, Carcache DA, Wagner J, Vulpetti A, Billich A, Dawson J, Kaupmann K, Kallen J, Stringer R, Orain D. Hintermann S, et al. Among authors: wagner j. ChemMedChem. 2016 Dec 16;11(24):2640-2648. doi: 10.1002/cmdc.201600500. Epub 2016 Nov 30. ChemMedChem. 2016. PMID: 27902884

10

Synthesis of macrolide analogues of sanglifehrin by RCM: unique reactivity of a ruthenium carbene complex bearing an imidazol-2-ylidene ligand. Ring-closing metathesis.

Wagner J, Martin Cabrejas LM, Grossmith CE, Papageorgiou C, Senia F, Wagner D, France J, Nolan SP. Wagner J, et al. Among authors: wagner d. J Org Chem. 2000 Dec 29;65(26):9255-60. doi: 10.1021/jo001296u. J Org Chem. 2000. PMID: 11149884 No abstract available.

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