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A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; ICGN Investigators; ECLIPSE Investigators; COPDGene Investigators. Cho MH, et al. Among authors: pillai sg. Hum Mol Genet. 2012 Feb 15;21(4):947-57. doi: 10.1093/hmg/ddr524. Epub 2011 Nov 11. Hum Mol Genet. 2012. PMID: 22080838 Free PMC article.
Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD.
Sørheim IC, DeMeo DL, Washko G, Litonjua A, Sparrow D, Bowler R, Bakke P, Pillai SG, Coxson HO, Lomas DA, Silverman EK, Hersh CP; International COPD Genetics Network Investigators. Sørheim IC, et al. Among authors: pillai sg. COPD. 2010 Aug;7(4):262-8. doi: 10.3109/15412555.2010.496821. COPD. 2010. PMID: 20673035 Free PMC article.
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.
Hersh CP, Hansel NN, Barnes KC, Lomas DA, Pillai SG, Coxson HO, Mathias RA, Rafaels NM, Wise RA, Connett JE, Klanderman BJ, Jacobson FL, Gill R, Litonjua AA, Sparrow D, Reilly JJ, Silverman EK; ICGN Investigators. Hersh CP, et al. Among authors: pillai sg. Am J Respir Cell Mol Biol. 2009 Sep;41(3):324-31. doi: 10.1165/rcmb.2008-0427OC. Epub 2009 Jan 8. Am J Respir Cell Mol Biol. 2009. PMID: 19131638 Free PMC article.
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.
Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lødrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB; ICGN Investigators. Pillai SG, et al. PLoS Genet. 2009 Mar;5(3):e1000421. doi: 10.1371/journal.pgen.1000421. Epub 2009 Mar 20. PLoS Genet. 2009. PMID: 19300482 Free PMC article.
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.
DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. DeMeo DL, et al. Among authors: pillai sg. Am J Hum Genet. 2009 Oct;85(4):493-502. doi: 10.1016/j.ajhg.2009.09.004. Am J Hum Genet. 2009. PMID: 19800047 Free PMC article.
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Cho MH, et al. Among authors: pillai sg. Nat Genet. 2010 Mar;42(3):200-2. doi: 10.1038/ng.535. Epub 2010 Feb 21. Nat Genet. 2010. PMID: 20173748 Free PMC article.
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
Hersh CP, Pillai SG, Zhu G, Lomas DA, Bakke P, Gulsvik A, DeMeo DL, Klanderman BJ, Lazarus R, Litonjua AA, Sparrow D, Reilly JJ, Agusti A, Calverley PM, Donner CF, Levy RD, Make BJ, Paré PD, Rennard SI, Vestbo J, Wouters EF, Scholand MB, Coon H, Hoidal J, Silverman EK. Hersh CP, et al. Among authors: pillai sg. Am J Respir Crit Care Med. 2010 Sep 1;182(5):605-13. doi: 10.1164/rccm.200910-1586OC. Epub 2010 May 12. Am J Respir Crit Care Med. 2010. PMID: 20463177 Free PMC article.
α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts.
Sørheim IC, Bakke P, Gulsvik A, Pillai SG, Johannessen A, Gaarder PI, Campbell EJ, Agustí A, Calverley PM, Donner CF, Make BJ, Rennard SI, Vestbo J, Wouters EF, Paré PD, Levy RD, Coxson HO, Lomas DA, Hersh CP, Silverman EK. Sørheim IC, et al. Among authors: pillai sg. Chest. 2010 Nov;138(5):1125-32. doi: 10.1378/chest.10-0746. Epub 2010 Jul 1. Chest. 2010. PMID: 20595457 Free PMC article.
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.
Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL; Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-Points (ECLIPSE); Norway-Bergen cohort; National Emphysema Treatment Trial; COPD Gene investigators. Wan ES, et al. Among authors: pillai sg. Am J Respir Cell Mol Biol. 2011 Aug;45(2):304-10. doi: 10.1165/rcmb.2010-0294OC. Epub 2010 Oct 29. Am J Respir Cell Mol Biol. 2011. PMID: 21037115 Free PMC article.
76 results