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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma.
Yokoyama S, Woods SL, Boyle GM, Aoude LG, MacGregor S, Zismann V, Gartside M, Cust AE, Haq R, Harland M, Taylor JC, Duffy DL, Holohan K, Dutton-Regester K, Palmer JM, Bonazzi V, Stark MS, Symmons J, Law MH, Schmidt C, Lanagan C, O'Connor L, Holland EA, Schmid H, Maskiell JA, Jetann J, Ferguson M, Jenkins MA, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Whiteman DC, Pharoah PD, Easton DF, Dunning AM, Newton-Bishop JA, Montgomery GW, Martin NG, Mann GJ, Bishop DT, Tsao H, Trent JM, Fisher DE, Hayward NK, Brown KM. Yokoyama S, et al. Among authors: haq r. Nature. 2011 Nov 13;480(7375):99-103. doi: 10.1038/nature10630. Nature. 2011. PMID: 22080950 Free PMC article.
YY1 regulates melanocyte development and function by cooperating with MITF.
Li J, Song JS, Bell RJ, Tran TN, Haq R, Liu H, Love KT, Langer R, Anderson DG, Larue L, Fisher DE. Li J, et al. Among authors: haq r. PLoS Genet. 2012;8(5):e1002688. doi: 10.1371/journal.pgen.1002688. Epub 2012 May 3. PLoS Genet. 2012. PMID: 22570637 Free PMC article.
PGC-1 coactivators regulate MITF and the tanning response.
Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. Shoag J, et al. Among authors: haq r. Mol Cell. 2013 Jan 10;49(1):145-57. doi: 10.1016/j.molcel.2012.10.027. Epub 2012 Nov 29. Mol Cell. 2013. PMID: 23201126 Free PMC article.
BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.
Haq R, Yokoyama S, Hawryluk EB, Jönsson GB, Frederick DT, McHenry K, Porter D, Tran TN, Love KT, Langer R, Anderson DG, Garraway LA, Duncan LM, Morton DL, Hoon DS, Wargo JA, Song JS, Fisher DE. Haq R, et al. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4321-6. doi: 10.1073/pnas.1205575110. Epub 2013 Feb 27. Proc Natl Acad Sci U S A. 2013. PMID: 23447565 Free PMC article.
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.
Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Haq R, et al. Cancer Cell. 2013 Mar 18;23(3):302-15. doi: 10.1016/j.ccr.2013.02.003. Epub 2013 Mar 7. Cancer Cell. 2013. PMID: 23477830 Free PMC article.
Targeting melanoma by small molecules: challenges ahead.
Haq R, Fisher DE. Haq R, et al. Pigment Cell Melanoma Res. 2013 Jul;26(4):464-9. doi: 10.1111/pcmr.12109. Epub 2013 May 28. Pigment Cell Melanoma Res. 2013. PMID: 23611259 Free PMC article. Review.
Improving apoptotic responses to targeted therapy.
Haq R, Fisher DE. Haq R, et al. Oncotarget. 2013 Sep;4(9):1331. doi: 10.18632/oncotarget.1261. Oncotarget. 2013. PMID: 23934756 Free PMC article. No abstract available.
190 results