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Association of IL-10-promoter genetic variants with the rate of CD4 T-cell loss, IL-10 plasma levels, and breadth of cytotoxic T-cell lymphocyte response during chronic HIV-1 infection.
Naicker DD, Wang B, Losina E, Zupkosky J, Bryan S, Reddy S, Jaggernath M, Mokgoro M, Goulder PJ, Kaufmann DE, Ndung'u T. Naicker DD, et al. Among authors: kaufmann de. Clin Infect Dis. 2012 Jan 15;54(2):294-302. doi: 10.1093/cid/cir811. Epub 2011 Nov 18. Clin Infect Dis. 2012. PMID: 22100578 Free PMC article.
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.
Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD. Day CL, et al. Among authors: kaufmann de. Nature. 2006 Sep 21;443(7109):350-4. doi: 10.1038/nature05115. Epub 2006 Aug 20. Nature. 2006. PMID: 16921384
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, Walker BD. Ramduth D, et al. Among authors: kaufmann de, de pierres c. PLoS One. 2009;4(4):e5013. doi: 10.1371/journal.pone.0005013. Epub 2009 Apr 7. PLoS One. 2009. PMID: 19352428 Free PMC article.
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Quigley M, et al. Among authors: kaufmann de. Nat Med. 2010 Oct;16(10):1147-51. doi: 10.1038/nm.2232. Epub 2010 Oct 3. Nat Med. 2010. PMID: 20890291 Free PMC article.
Responsiveness of HIV-specific CD4 T cells to PD-1 blockade.
Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE. Porichis F, et al. Among authors: kaufmann de. Blood. 2011 Jul 28;118(4):965-74. doi: 10.1182/blood-2010-12-328070. Epub 2011 Jun 7. Blood. 2011. PMID: 21652684 Free PMC article.
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law K, Hongo TC, Pyo A, Piechocka-Trocha A, Toth I, Pereyra F, Ghebremichael M, Rodig SJ, Milner DA Jr, Richter JM, Altfeld M, Kaufmann DE, Walker BD, Addo MM. Angin M, et al. Among authors: kaufmann de. J Infect Dis. 2012 May 15;205(10):1495-500. doi: 10.1093/infdis/jis236. Epub 2012 Mar 15. J Infect Dis. 2012. PMID: 22427677 Free PMC article.
Tuberculosis distorts the inhibitory impact of interleukin-10 in HIV infection.
Chetty S, Porichis F, Govender P, Zupkosky J, Ghebremichael M, Pillay M, Walker BD, Ndung'u T, Kaufmann DE, Kasprowicz VO. Chetty S, et al. Among authors: kaufmann de. AIDS. 2014 Nov 28;28(18):2671-6. doi: 10.1097/QAD.0000000000000437. AIDS. 2014. PMID: 25211438 Free PMC article.
215 results