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Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Zhou QD, et al. Among authors: williams kj. Nat Immunol. 2020 Jul;21(7):746-755. doi: 10.1038/s41590-020-0695-4. Epub 2020 Jun 8. Nat Immunol. 2020. PMID: 32514064 Free PMC article.
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.
Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. Hsieh WY, et al. Among authors: williams kj. Cell Metab. 2020 Jul 7;32(1):128-143.e5. doi: 10.1016/j.cmet.2020.05.003. Epub 2020 Jun 8. Cell Metab. 2020. PMID: 32516576 Free PMC article.
IL-10 constrains sphingolipid metabolism to limit inflammation.
York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. York AG, et al. Among authors: williams kj. Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. Epub 2024 Feb 21. Nature. 2024. PMID: 38383790 Free PMC article.
Dynamic lipidome alterations associated with human health, disease and ageing.
Hornburg D, Wu S, Moqri M, Zhou X, Contrepois K, Bararpour N, Traber GM, Su B, Metwally AA, Avina M, Zhou W, Ubellacker JM, Mishra T, Schüssler-Fiorenza Rose SM, Kavathas PB, Williams KJ, Snyder MP. Hornburg D, et al. Among authors: williams kj. Nat Metab. 2023 Sep;5(9):1578-1594. doi: 10.1038/s42255-023-00880-1. Epub 2023 Sep 11. Nat Metab. 2023. PMID: 37697054 Free PMC article.
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Kidani Y, et al. Among authors: williams kj. Nat Immunol. 2013 May;14(5):489-99. doi: 10.1038/ni.2570. Epub 2013 Apr 7. Nat Immunol. 2013. PMID: 23563690 Free PMC article.
Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.
Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE. Eyme KM, et al. Among authors: williams kj. Sci Transl Med. 2023 Jan 18;15(679):eabq6288. doi: 10.1126/scitranslmed.abq6288. Epub 2023 Jan 18. Sci Transl Med. 2023. PMID: 36652537 Free PMC article.
627 results