McInally T - Search Results

1

Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity.

Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM. Biffen M, et al. Among authors: mcinally t. Br J Pharmacol. 2012 May;166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x. Br J Pharmacol. 2012. PMID: 22122192 Free PMC article.

2

Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

Kurimoto A, Hashimoto K, Nakamura T, Norimura K, Ogita H, Takaku H, Bonnert R, McInally T, Wada H, Isobe Y. Kurimoto A, et al. Among authors: mcinally t. J Med Chem. 2010 Apr 8;53(7):2964-72. doi: 10.1021/jm100070n. J Med Chem. 2010. PMID: 20232824

3

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Nakamura T, Wada H, Kurebayashi H, McInally T, Bonnert R, Isobe Y. Nakamura T, et al. Among authors: mcinally t. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72. doi: 10.1016/j.bmcl.2012.11.114. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23265901

4

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.

Luker T, Bonnert R, Schmidt J, Sargent C, Paine SW, Thom S, Pairaudeau G, Patel A, Mohammed R, Akam E, Dougall I, Davis AM, Abbott P, Brough S, Millichip I, McInally T. Luker T, et al. Among authors: mcinally t. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. doi: 10.1016/j.bmcl.2011.04.101. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21592791

5

1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.

Tinker AC, Beaton HG, Boughton-Smith N, Cook TR, Cooper SL, Fraser-Rae L, Hallam K, Hamley P, McInally T, Nicholls DJ, Pimm AD, Wallace AV. Tinker AC, et al. Among authors: mcinally t. J Med Chem. 2003 Mar 13;46(6):913-6. doi: 10.1021/jm0255926. J Med Chem. 2003. PMID: 12620067

6

Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists.

Baxter A, Bent J, Bowers K, Braddock M, Brough S, Fagura M, Lawson M, McInally T, Mortimore M, Robertson M, Weaver R, Webborn P. Baxter A, et al. Among authors: mcinally t. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4047-50. doi: 10.1016/j.bmcl.2003.08.034. Bioorg Med Chem Lett. 2003. PMID: 14592505

7

Hit-to-lead studies: the discovery of potent, orally bioavailable triazolethiol CXCR2 receptor antagonists.

Baxter A, Bennion C, Bent J, Boden K, Brough S, Cooper A, Kinchin E, Kindon N, McInally T, Mortimore M, Roberts B, Unitt J. Baxter A, et al. Among authors: mcinally t. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2625-8. doi: 10.1016/s0960-894x(03)00561-4. Bioorg Med Chem Lett. 2003. PMID: 12873480

8

Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors.

Baxter A, Brough S, Cooper A, Floettmann E, Foster S, Harding C, Kettle J, McInally T, Martin C, Mobbs M, Needham M, Newham P, Paine S, St-Gallay S, Salter S, Unitt J, Xue Y. Baxter A, et al. Among authors: mcinally t. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22. doi: 10.1016/j.bmcl.2004.03.058. Bioorg Med Chem Lett. 2004. PMID: 15125939

9

Unusual Undergraduate Training in Medicinal Chemistry in Collaboration between Academia and Industry.

McInally T, Macdonald SJF. McInally T, et al. J Med Chem. 2017 Oct 12;60(19):7958-7964. doi: 10.1021/acs.jmedchem.7b00198. Epub 2017 May 23. J Med Chem. 2017. PMID: 28535049 Review.

10

Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.

Adams J, Anderson EC, Blackham EE, Chiu YW, Clarke T, Eccles N, Gill LA, Haye JJ, Haywood HT, Hoenig CR, Kausas M, Le J, Russell HL, Smedley C, Tipping WJ, Tongue T, Wood CC, Yeung J, Rowedder JE, Fray MJ, McInally T, Macdonald SJ. Adams J, et al. Among authors: mcinally t. ACS Med Chem Lett. 2014 Sep 19;5(11):1207-12. doi: 10.1021/ml5002079. eCollection 2014 Nov 13. ACS Med Chem Lett. 2014. PMID: 25408832 Free PMC article.

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