Holman TR - Search Results

1

Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation.

Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Yeung J, et al. Among authors: holman tr. Mol Pharmacol. 2012 Mar;81(3):420-30. doi: 10.1124/mol.111.075630. Epub 2011 Dec 9. Mol Pharmacol. 2012. PMID: 22155783 Free PMC article.

2

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity.

van Hoorebeke C, Yang K, Mussetter SJ, Koch G, Rutz N, Lokey RS, Crews P, Holman TR. van Hoorebeke C, et al. Among authors: holman tr. ACS Omega. 2022 Nov 17;7(47):43169-43179. doi: 10.1021/acsomega.2c05877. eCollection 2022 Nov 29. ACS Omega. 2022. PMID: 36467910 Free PMC article.

3

Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.

Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Segraves EN, et al. Among authors: holman tr. J Med Chem. 2004 Jul 29;47(16):4060-5. doi: 10.1021/jm049872s. J Med Chem. 2004. PMID: 15267244

4

Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1.

Ruddat VC, Mogul R, Chorny I, Chen C, Perrin N, Whitman S, Kenyon V, Jacobson MP, Bernasconi CF, Holman TR. Ruddat VC, et al. Among authors: holman tr. Biochemistry. 2004 Oct 19;43(41):13063-71. doi: 10.1021/bi0489098. Biochemistry. 2004. PMID: 15476400

5

Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors.

Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Cichewicz RH, et al. Among authors: holman tr. J Am Chem Soc. 2004 Nov 17;126(45):14910-20. doi: 10.1021/ja046082z. J Am Chem Soc. 2004. PMID: 15535718

6

Novel human lipoxygenase inhibitors discovered using virtual screening with homology models.

Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Kenyon V, et al. Among authors: holman tr. J Med Chem. 2006 Feb 23;49(4):1356-63. doi: 10.1021/jm050639j. J Med Chem. 2006. PMID: 16480270

7

Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases.

Deschamps JD, Kenyon VA, Holman TR. Deschamps JD, et al. Among authors: holman tr. Bioorg Med Chem. 2006 Jun 15;14(12):4295-301. doi: 10.1016/j.bmc.2006.01.057. Epub 2006 Feb 24. Bioorg Med Chem. 2006. PMID: 16500106

8

Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2.

Vasquez-Martinez Y, Ohri RV, Kenyon V, Holman TR, Sepúlveda-Boza S. Vasquez-Martinez Y, et al. Among authors: holman tr. Bioorg Med Chem. 2007 Dec 1;15(23):7408-25. doi: 10.1016/j.bmc.2007.07.036. Epub 2007 Aug 22. Bioorg Med Chem. 2007. PMID: 17869117 Free PMC article.

9

Novel lipoxygenase inhibitors as neuroprotective reagents.

van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. van Leyen K, et al. Among authors: holman tr. J Neurosci Res. 2008 Mar;86(4):904-9. doi: 10.1002/jnr.21543. J Neurosci Res. 2008. PMID: 17960827 Free PMC article.

10

Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.

Wecksler AT, Kenyon V, Deschamps JD, Holman TR. Wecksler AT, et al. Among authors: holman tr. Biochemistry. 2008 Jul 15;47(28):7364-75. doi: 10.1021/bi800550n. Epub 2008 Jun 21. Biochemistry. 2008. PMID: 18570379 Free PMC article.

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