MacKenzie RE - Search Results

1

A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development.

Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R. Christensen KE, et al. Among authors: mackenzie re. Hum Mol Genet. 2013 Sep 15;22(18):3705-19. doi: 10.1093/hmg/ddt223. Epub 2013 May 23. Hum Mol Genet. 2013. PMID: 23704330

2

Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.

Sutton JM, Clark DE, Dunsdon SJ, Fenton G, Fillmore A, Harris NV, Higgs C, Hurley CA, Krintel SL, MacKenzie RE, Duttaroy A, Gangl E, Maniara W, Sedrani R, Namoto K, Ostermann N, Gerhartz B, Sirockin F, Trappe J, Hassiepen U, Baeschlin DK. Sutton JM, et al. Among authors: mackenzie re. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1464-8. doi: 10.1016/j.bmcl.2011.11.054. Epub 2011 Nov 20. Bioorg Med Chem Lett. 2012. PMID: 22177783

3

Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases.

Christensen KE, Mackenzie RE. Christensen KE, et al. Among authors: mackenzie re. Vitam Horm. 2008;79:393-410. doi: 10.1016/S0083-6729(08)00414-7. Vitam Horm. 2008. PMID: 18804703 Review.

4

The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects.

Christensen KE, Rohlicek CV, Andelfinger GU, Michaud J, Bigras JL, Richter A, Mackenzie RE, Rozen R. Christensen KE, et al. Among authors: mackenzie re. Hum Mutat. 2009 Feb;30(2):212-20. doi: 10.1002/humu.20830. Hum Mutat. 2009. PMID: 18767138

5

Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals.

Christensen KE, MacKenzie RE. Christensen KE, et al. Among authors: mackenzie re. Bioessays. 2006 Jun;28(6):595-605. doi: 10.1002/bies.20420. Bioessays. 2006. PMID: 16700064 Review.

6

NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts.

Patel H, Di Pietro E, Mejia N, MacKenzie RE. Patel H, et al. Among authors: mackenzie re. Arch Biochem Biophys. 2005 Oct 1;442(1):133-9. doi: 10.1016/j.abb.2005.07.022. Arch Biochem Biophys. 2005. PMID: 16150419

7

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.

Christensen KE, Mirza IA, Berghuis AM, Mackenzie RE. Christensen KE, et al. Among authors: mackenzie re. J Biol Chem. 2005 Oct 7;280(40):34316-23. doi: 10.1074/jbc.M505210200. Epub 2005 Aug 11. J Biol Chem. 2005. PMID: 16100107 Free article.

8

Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.

Christensen KE, Patel H, Kuzmanov U, Mejia NR, MacKenzie RE. Christensen KE, et al. Among authors: mackenzie re. J Biol Chem. 2005 Mar 4;280(9):7597-602. doi: 10.1074/jbc.M409380200. Epub 2004 Dec 16. J Biol Chem. 2005. PMID: 15611115 Free article.

9

The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth.

Di Pietro E, Wang XL, MacKenzie RE. Di Pietro E, et al. Among authors: mackenzie re. Biochim Biophys Acta. 2004 Sep 6;1674(1):78-84. doi: 10.1016/j.bbagen.2004.06.014. Biochim Biophys Acta. 2004. PMID: 15342116

10

The molecular basis of glutamate formiminotransferase deficiency.

Hilton JF, Christensen KE, Watkins D, Raby BA, Renaud Y, de la Luna S, Estivill X, MacKenzie RE, Hudson TJ, Rosenblatt DS. Hilton JF, et al. Among authors: mackenzie re. Hum Mutat. 2003 Jul;22(1):67-73. doi: 10.1002/humu.10236. Hum Mutat. 2003. PMID: 12815595

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