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Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate.
Alvarenga PH, Xu X, Oliveira F, Chagas AC, Nascimento CR, Francischetti IM, Juliano MA, Juliano L, Scharfstein J, Valenzuela JG, Ribeiro JM, Andersen JF. Alvarenga PH, et al. Among authors: chagas ac. Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2759-70. doi: 10.1161/ATVBAHA.113.302482. Epub 2013 Oct 3. Arterioscler Thromb Vasc Biol. 2013. PMID: 24092749 Free PMC article.
Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.
Chagas AC, McPhie P, San H, Narum D, Reiter K, Tokomasu F, Brayner FA, Alves LC, Ribeiro JM, Calvo E. Chagas AC, et al. PLoS Negl Trop Dis. 2014 Jun 12;8(6):e2947. doi: 10.1371/journal.pntd.0002947. eCollection 2014 Jun. PLoS Negl Trop Dis. 2014. PMID: 24921659 Free PMC article.
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.
Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF. Wang X, et al. Among authors: chagas ac. Infect Immun. 2016 May 24;84(6):1796-1805. doi: 10.1128/IAI.01526-15. Print 2016 Jun. Infect Immun. 2016. PMID: 27045038 Free PMC article.
Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection.
Martin-Martin I, Chagas AC, Guimaraes-Costa AB, Amo L, Oliveira F, Moore IN, DeSouza-Vieira TS, Sanchez EE, Suntravat M, Valenzuela JG, Ribeiro JMC, Calvo E. Martin-Martin I, et al. Among authors: chagas ac. PLoS Pathog. 2018 May 3;14(5):e1007006. doi: 10.1371/journal.ppat.1007006. eCollection 2018 May. PLoS Pathog. 2018. PMID: 29723281 Free PMC article.
175 results