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Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.
Carpinelli MR, Hilton DJ, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS. Carpinelli MR, et al. Among authors: hilton aa. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8. doi: 10.1073/pnas.0401496101. Epub 2004 Apr 7. Proc Natl Acad Sci U S A. 2004. PMID: 15071178 Free PMC article.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ. Alexander WS, et al. Among authors: hilton aa. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16442-7. doi: 10.1073/pnas.0607872103. Epub 2006 Oct 24. Proc Natl Acad Sci U S A. 2006. PMID: 17062753 Free PMC article.
Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.
Stevenson WS, Hyland CD, Zhang JG, Morgan PO, Willson TA, Gill A, Hilton AA, Viney EM, Bahlo M, Masters SL, Hennebry S, Richardson SJ, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS. Stevenson WS, et al. Among authors: hilton aa. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16625-30. doi: 10.1073/pnas.1010390107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823251 Free PMC article.
Programmed anuclear cell death delimits platelet life span.
Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT. Mason KD, et al. Among authors: hilton aa. Cell. 2007 Mar 23;128(6):1173-86. doi: 10.1016/j.cell.2007.01.037. Cell. 2007. PMID: 17382885 Free article.
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ. Majewski IJ, et al. Among authors: hilton aa. PLoS Biol. 2008 Apr 15;6(4):e93. doi: 10.1371/journal.pbio.0060093. PLoS Biol. 2008. PMID: 18416604 Free PMC article.
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Hildebrand JM, Kauppi M, Majewski IJ, Liu Z, Cox AJ, Miyake S, Petrie EJ, Silk MA, Li Z, Tanzer MC, Brumatti G, Young SN, Hall C, Garnish SE, Corbin J, Stutz MD, Di Rago L, Gangatirkar P, Josefsson EC, Rigbye K, Anderton H, Rickard JA, Tripaydonis A, Sheridan J, Scerri TS, Jackson VE, Czabotar PE, Zhang JG, Varghese L, Allison CC, Pellegrini M, Tannahill GM, Hatchell EC, Willson TA, Stockwell D, de Graaf CA, Collinge J, Hilton A, Silke N, Spall SK, Chau D, Athanasopoulos V, Metcalf D, Laxer RM, Bassuk AG, Darbro BW, Fiatarone Singh MA, Vlahovich N, Hughes D, Kozlovskaia M, Ascher DB, Warnatz K, Venhoff N, Thiel J, Biben C, Blum S, Reveille J, Hildebrand MS, Vinuesa CG, McCombe P, Brown MA, Kile BT, McLean C, Bahlo M, Masters SL, Nakano H, Ferguson PJ, Murphy JM, Alexander WS, Silke J. Hildebrand JM, et al. Nat Commun. 2020 Jun 19;11(1):3150. doi: 10.1038/s41467-020-16819-z. Nat Commun. 2020. PMID: 32561755 Free PMC article.
A novel mutation in the Nfkb2 gene generates an NF-kappa B2 "super repressor".
Tucker E, O'Donnell K, Fuchsberger M, Hilton AA, Metcalf D, Greig K, Sims NA, Quinn JM, Alexander WS, Hilton DJ, Kile BT, Tarlinton DM, Starr R. Tucker E, et al. Among authors: hilton aa. J Immunol. 2007 Dec 1;179(11):7514-22. doi: 10.4049/jimmunol.179.11.7514. J Immunol. 2007. PMID: 18025196
17 results