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Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity.
Creemers JW, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, Meulemans S, Than ME, Yengo L, Tauber M, Balkau B, Elliott P, Jarvelin MR, Van Hul W, Van Gaal L, Horber F, Pattou F, Froguel P, Meyre D. Creemers JW, et al. Among authors: van gaal l, van hul w. Diabetes. 2012 Feb;61(2):383-90. doi: 10.2337/db11-0305. Epub 2011 Dec 30. Diabetes. 2012. PMID: 22210313 Free PMC article.
Prevalence of loss-of-function FTO mutations in lean and obese individuals.
Meyre D, Proulx K, Kawagoe-Takaki H, Vatin V, Gutiérrez-Aguilar R, Lyon D, Ma M, Choquet H, Horber F, Van Hul W, Van Gaal L, Balkau B, Visvikis-Siest S, Pattou F, Farooqi IS, Saudek V, O'Rahilly S, Froguel P, Sedgwick B, Yeo GS. Meyre D, et al. Among authors: van gaal l, van hul w. Diabetes. 2010 Jan;59(1):311-8. doi: 10.2337/db09-0703. Epub 2009 Oct 15. Diabetes. 2010. PMID: 19833892 Free PMC article.
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Ichimura A, et al. Among authors: van gaal l, van hul w. Nature. 2012 Feb 19;483(7389):350-4. doi: 10.1038/nature10798. Nature. 2012. PMID: 22343897 Free article.
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features.
Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, Weill J, Miller JL, Horber F, Goldstone AP, Driscoll DJ, Bruning JB, Meyre D, Whitelaw ML, Froguel P. Bonnefond A, et al. Among authors: van gaal l, van hul w. J Clin Invest. 2013 Jul;123(7):3037-41. doi: 10.1172/JCI68035. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778136 Free PMC article.
Screening for genetic variants in BDNF that contribute to childhood obesity.
Zegers D, Hendrickx R, Verrijken A, Van Hoorenbeeck K, Van Camp JK, de Craemer V, Rooman RP, Desager KN, Massa G, Van Gaal LF, Van Hul W, Beckers S. Zegers D, et al. Among authors: van gaal lf, van hoorenbeeck k, van camp jk, van hul w. Pediatr Obes. 2014 Feb;9(1):36-42. doi: 10.1111/j.2047-6310.2012.00131.x. Epub 2013 Jan 16. Pediatr Obes. 2014. PMID: 23325614
Association of the BDNF Val66Met variation with obesity in women.
Beckers S, Peeters A, Zegers D, Mertens I, Van Gaal L, Van Hul W. Beckers S, et al. Among authors: van gaal l, van hul w. Mol Genet Metab. 2008 Sep-Oct;95(1-2):110-2. doi: 10.1016/j.ymgme.2008.06.008. Epub 2008 Jul 29. Mol Genet Metab. 2008. PMID: 18667348
Mutation screen of the SIM1 gene in pediatric patients with early-onset obesity.
Zegers D, Beckers S, Hendrickx R, Van Camp JK, de Craemer V, Verrijken A, Van Hoorenbeeck K, Verhulst SL, Rooman RP, Desager KN, Massa G, Van Gaal LF, Van Hul W. Zegers D, et al. Among authors: van gaal lf, van hoorenbeeck k, van camp jk, van hul w. Int J Obes (Lond). 2014 Jul;38(7):1000-4. doi: 10.1038/ijo.2013.188. Epub 2013 Oct 7. Int J Obes (Lond). 2014. PMID: 24097297
471 results