Overkleeft HS - Search Results

1

Proteasome inhibitors: an expanding army attacking a unique target.

Kisselev AF, van der Linden WA, Overkleeft HS. Kisselev AF, et al. Among authors: overkleeft hs. Chem Biol. 2012 Jan 27;19(1):99-115. doi: 10.1016/j.chembiol.2012.01.003. Chem Biol. 2012. PMID: 22284358 Free PMC article. Review.

2

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.

Kraus M, Bader J, Geurink PP, Weyburne ES, Mirabella AC, Silzle T, Shabaneh TB, van der Linden WA, de Bruin G, Haile SR, van Rooden E, Appenzeller C, Li N, Kisselev AF, Overkleeft H, Driessen C. Kraus M, et al. Haematologica. 2015 Oct;100(10):1350-60. doi: 10.3324/haematol.2014.109421. Epub 2015 Jun 11. Haematologica. 2015. PMID: 26069288 Free PMC article.

3

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.

Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Britton M, et al. Among authors: overkleeft hs. Chem Biol. 2009 Dec 24;16(12):1278-89. doi: 10.1016/j.chembiol.2009.11.015. Chem Biol. 2009. PMID: 20064438 Free PMC article.

4

Nature of pharmacophore influences active site specificity of proteasome inhibitors.

Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF. Screen M, et al. Among authors: overkleeft hs. J Biol Chem. 2010 Dec 17;285(51):40125-34. doi: 10.1074/jbc.M110.160606. Epub 2010 Oct 11. J Biol Chem. 2010. PMID: 20937826 Free PMC article.

5

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.

Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Mirabella AC, et al. Among authors: overkleeft hs. Chem Biol. 2011 May 27;18(5):608-18. doi: 10.1016/j.chembiol.2011.02.015. Chem Biol. 2011. PMID: 21609842 Free PMC article.

6

Use of proteasome inhibitors.

Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Downey SL, et al. Among authors: overkleeft hs. Curr Protoc Immunol. 2015 Apr 1;109:9.10.1-9.10.8. doi: 10.1002/0471142735.im0910s109. Curr Protoc Immunol. 2015. PMID: 25845565

7

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.

de Bruin G, Xin BT, Kraus M, van der Stelt M, van der Marel GA, Kisselev AF, Driessen C, Florea BI, Overkleeft HS. de Bruin G, et al. Among authors: overkleeft hs. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4199-203. doi: 10.1002/anie.201509092. Epub 2015 Oct 29. Angew Chem Int Ed Engl. 2016. PMID: 26511210

8

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.

Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS. Xin BT, et al. Among authors: overkleeft hs. J Med Chem. 2016 Aug 11;59(15):7177-87. doi: 10.1021/acs.jmedchem.6b00705. Epub 2016 Aug 1. J Med Chem. 2016. PMID: 27438186

9

An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors.

Downey-Kopyscinski S, Daily EW, Gautier M, Bhatt A, Florea BI, Mitsiades CS, Richardson PG, Driessen C, Overkleeft HS, Kisselev AF. Downey-Kopyscinski S, et al. Among authors: overkleeft hs. Blood Adv. 2018 Oct 9;2(19):2443-2451. doi: 10.1182/bloodadvances.2018016360. Blood Adv. 2018. PMID: 30266819 Free PMC article.

10

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. Kisselev AF, et al. Among authors: overkleeft hs. J Biol Chem. 2003 Sep 19;278(38):35869-77. doi: 10.1074/jbc.M303725200. Epub 2003 Jun 18. J Biol Chem. 2003. PMID: 12815064 Free article.

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