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Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
Bonnefond A, Clément N, Fawcett K, Yengo L, Vaillant E, Guillaume JL, Dechaume A, Payne F, Roussel R, Czernichow S, Hercberg S, Hadjadj S, Balkau B, Marre M, Lantieri O, Langenberg C, Bouatia-Naji N; Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC); Charpentier G, Vaxillaire M, Rocheleau G, Wareham NJ, Sladek R, McCarthy MI, Dina C, Barroso I, Jockers R, Froguel P. Bonnefond A, et al. Among authors: jockers r. Nat Genet. 2012 Jan 29;44(3):297-301. doi: 10.1038/ng.1053. Nat Genet. 2012. PMID: 22286214 Free PMC article.
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Couturier C, Sarkis C, Séron K, Belouzard S, Chen P, Lenain A, Corset L, Dam J, Vauthier V, Dubart A, Mallet J, Froguel P, Rouillé Y, Jockers R. Couturier C, et al. Among authors: jockers r. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19476-81. doi: 10.1073/pnas.0706671104. Epub 2007 Nov 27. Proc Natl Acad Sci U S A. 2007. PMID: 18042720 Free PMC article.
Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.
Chaste P, Clement N, Mercati O, Guillaume JL, Delorme R, Botros HG, Pagan C, Périvier S, Scheid I, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg C, Serrano E, Lemière N, Launay JM, Mouren-Simeoni MC, Leboyer M, Gillberg C, Jockers R, Bourgeron T. Chaste P, et al. Among authors: jockers r. PLoS One. 2010 Jul 15;5(7):e11495. doi: 10.1371/journal.pone.0011495. PLoS One. 2010. PMID: 20657642 Free PMC article.
Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) coupling.
Maurice P, Daulat AM, Turecek R, Ivankova-Susankova K, Zamponi F, Kamal M, Clement N, Guillaume JL, Bettler B, Galès C, Delagrange P, Jockers R. Maurice P, et al. Among authors: jockers r. EMBO J. 2010 Nov 3;29(21):3646-59. doi: 10.1038/emboj.2010.236. Epub 2010 Sep 21. EMBO J. 2010. PMID: 20859254 Free PMC article.
209 results