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High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C.
Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H, Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J. Willander H, et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2325-9. doi: 10.1073/pnas.1114740109. Epub 2012 Feb 2. Proc Natl Acad Sci U S A. 2012. PMID: 22308375 Free PMC article.
BRICHOS domains efficiently delay fibrillation of amyloid β-peptide.
Willander H, Presto J, Askarieh G, Biverstål H, Frohm B, Knight SD, Johansson J, Linse S. Willander H, et al. J Biol Chem. 2012 Sep 7;287(37):31608-17. doi: 10.1074/jbc.M112.393157. Epub 2012 Jul 16. J Biol Chem. 2012. PMID: 22801430 Free PMC article.
Proinsulin C-peptide interferes with insulin fibril formation.
Landreh M, Stukenborg JB, Willander H, Söder O, Johansson J, Jörnvall H. Landreh M, et al. Among authors: willander h. Biochem Biophys Res Commun. 2012 Feb 17;418(3):489-93. doi: 10.1016/j.bbrc.2012.01.051. Epub 2012 Jan 18. Biochem Biophys Res Commun. 2012. PMID: 22281499