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Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration.
Croteau D, Best BM, Letendre S, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Grant I; CHARTER Group. Croteau D, et al. Among authors: letendre s. AIDS. 2012 Apr 24;26(7):890-3. doi: 10.1097/QAD.0b013e328351f627. AIDS. 2012. PMID: 22313954 Free PMC article.
Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance.
Marra CM, Zhao Y, Clifford DB, Letendre S, Evans S, Henry K, Ellis RJ, Rodriguez B, Coombs RW, Schifitto G, McArthur JC, Robertson K; AIDS Clinical Trials Group 736 Study Team. Marra CM, et al. Among authors: letendre s. AIDS. 2009 Jul 17;23(11):1359-66. doi: 10.1097/QAD.0b013e32832c4152. AIDS. 2009. PMID: 19424052 Free PMC article. Clinical Trial.
Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1.
Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I; CHARTER Group. Croteau D, et al. Among authors: letendre s. Antimicrob Agents Chemother. 2010 Dec;54(12):5156-60. doi: 10.1128/AAC.00507-10. Epub 2010 Sep 27. Antimicrob Agents Chemother. 2010. PMID: 20876368 Free PMC article.
Efavirenz concentrations in CSF exceed IC50 for wild-type HIV.
Best BM, Koopmans PP, Letendre SL, Capparelli EV, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I; CHARTER Group. Best BM, et al. Among authors: letendre sl. J Antimicrob Chemother. 2011 Feb;66(2):354-7. doi: 10.1093/jac/dkq434. Epub 2010 Nov 23. J Antimicrob Chemother. 2011. PMID: 21098541 Free PMC article.
Therapeutic amprenavir concentrations in cerebrospinal fluid.
Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I; CHARTER Group. Croteau D, et al. Among authors: letendre s. Antimicrob Agents Chemother. 2012 Apr;56(4):1985-9. doi: 10.1128/AAC.05098-11. Epub 2012 Jan 30. Antimicrob Agents Chemother. 2012. PMID: 22290964 Free PMC article.
Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration.
Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S; CHARTER Group. Croteau D, et al. Among authors: letendre s. J Antimicrob Chemother. 2013 Mar;68(3):684-9. doi: 10.1093/jac/dks441. Epub 2012 Nov 9. J Antimicrob Chemother. 2013. PMID: 23143899 Free PMC article.
Etravirine in CSF is highly protein bound.
Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S; CHARTER Group. Nguyen A, et al. Among authors: letendre s. J Antimicrob Chemother. 2013 May;68(5):1161-8. doi: 10.1093/jac/dks517. Epub 2013 Jan 20. J Antimicrob Chemother. 2013. PMID: 23335197 Free PMC article.
Cerebrospinal fluid viral escape in aviremic HIV-infected patients receiving antiretroviral therapy: prevalence, risk factors and neurocognitive effects.
Pérez-Valero I, Ellis R, Heaton R, Deutsch R, Franklin D, Clifford DB, Collier A, Gelman B, Marra C, McCutchan JA, Navis A, Sacktor N, Simpson D, Grant I, Letendre S. Pérez-Valero I, et al. Among authors: letendre s. AIDS. 2019 Mar 1;33(3):475-481. doi: 10.1097/QAD.0000000000002074. AIDS. 2019. PMID: 30702516 Free PMC article.
472 results