Exell JC - Search Results

1

Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA. Patel N, et al. Among authors: exell jc. Nucleic Acids Res. 2012 May;40(10):4507-19. doi: 10.1093/nar/gks051. Epub 2012 Feb 8. Nucleic Acids Res. 2012. PMID: 22319208 Free PMC article.

2

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.

Finger LD, Patel N, Beddows A, Ma L, Exell JC, Jardine E, Jones AC, Grasby JA. Finger LD, et al. Among authors: exell jc. Nucleic Acids Res. 2013 Nov;41(21):9839-47. doi: 10.1093/nar/gkt737. Epub 2013 Aug 23. Nucleic Acids Res. 2013. PMID: 23975198 Free PMC article.

3

Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.

Patel N, Exell JC, Jardine E, Ombler B, Finger LD, Ciani B, Grasby JA. Patel N, et al. Among authors: exell jc. J Biol Chem. 2013 Nov 22;288(47):34239-34248. doi: 10.1074/jbc.M113.509489. Epub 2013 Oct 14. J Biol Chem. 2013. PMID: 24126913 Free PMC article.

4

DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction.

Algasaier SI, Exell JC, Bennet IA, Thompson MJ, Gotham VJ, Shaw SJ, Craggs TD, Finger LD, Grasby JA. Algasaier SI, et al. Among authors: exell jc. J Biol Chem. 2016 Apr 8;291(15):8258-68. doi: 10.1074/jbc.M115.698993. Epub 2016 Feb 16. J Biol Chem. 2016. PMID: 26884332 Free PMC article.

5

Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.

Bennet IA, Finger LD, Baxter NJ, Ambrose B, Hounslow AM, Thompson MJ, Exell JC, Shahari NNBM, Craggs TD, Waltho JP, Grasby JA. Bennet IA, et al. Among authors: exell jc. Nucleic Acids Res. 2018 Jun 20;46(11):5618-5633. doi: 10.1093/nar/gky293. Nucleic Acids Res. 2018. PMID: 29718417 Free PMC article.

6

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.

Exell JC, Thompson MJ, Finger LD, Shaw SJ, Debreczeni J, Ward TA, McWhirter C, Siöberg CL, Martinez Molina D, Abbott WM, Jones CD, Nissink JW, Durant ST, Grasby JA. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21. doi: 10.1038/nchembio.2148. Epub 2016 Aug 15. Nat Chem Biol. 2016. PMID: 27526030 Free PMC article.

7

Real-time 3D single molecule tracking.

Hou S, Exell J, Welsher K. Hou S, et al. Nat Commun. 2020 Jul 17;11(1):3607. doi: 10.1038/s41467-020-17444-6. Nat Commun. 2020. PMID: 32680983 Free PMC article.

8

Continuous focal translation enhances rate of point-scan volumetric microscopy.

Johnson C, Exell J, Kuo J, Welsher K. Johnson C, et al. Opt Express. 2019 Dec 9;27(25):36241-36258. doi: 10.1364/OE.27.036241. Opt Express. 2019. PMID: 31873407 Free PMC article.

9

Direct Fluorescent Imaging of Translocation and Unwinding by Individual DNA Helicases.

Pavankumar TL, Exell JC, Kowalczykowski SC. Pavankumar TL, et al. Among authors: exell jc. Methods Enzymol. 2016;581:1-32. doi: 10.1016/bs.mie.2016.09.010. Epub 2016 Oct 18. Methods Enzymol. 2016. PMID: 27793277 Free PMC article.

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