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Page 1
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Ramamurthy V, Krystek SR Jr, Bush A, Wei A, Emanuel SL, Das Gupta R, Janjua A, Cheng L, Murdock M, Abramczyk B, Cohen D, Lin Z, Morin P, Davis JH, Dabritz M, McLaughlin DC, Russo KA, Chao G, Wright MC, Jenny VA, Engle LJ, Furfine E, Sheriff S. Ramamurthy V, et al. Among authors: wright mc. Structure. 2012 Feb 8;20(2):259-69. doi: 10.1016/j.str.2011.11.016. Structure. 2012. PMID: 22325775 Free article.
A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.
Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, Yamniuk AP, Hosbach J, Brown J, Fitzpatrick E, Gokemeijer J, Morin P, Morse BA, Carvajal IM, Fabrizio D, Wright MC, Das Gupta R, Gosselin M, Cataldo D, Ryseck RP, Doyle ML, Wong TW, Camphausen RT, Cload ST, Marsh HN, Gottardis MM, Furfine ES. Emanuel SL, et al. Among authors: wright mc. MAbs. 2011 Jan-Feb;3(1):38-48. doi: 10.4161/mabs.3.1.14168. Epub 2011 Jan 1. MAbs. 2011. PMID: 21099371 Free PMC article.
Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.
Khan JA, Camac DM, Low S, Tebben AJ, Wensel DL, Wright MC, Su J, Jenny V, Gupta RD, Ruzanov M, Russo KA, Bell A, An Y, Bryson JW, Gao M, Gambhire P, Baldwin ET, Gardner D, Cavallaro CL, Duncia JV, Hynes J Jr. Khan JA, et al. Among authors: wright mc. J Mol Biol. 2015 Feb 27;427(4):924-942. doi: 10.1016/j.jmb.2014.12.022. Epub 2015 Jan 8. J Mol Biol. 2015. PMID: 25579995
Anti-tumor effect of CT-322 as an adnectin inhibitor of vascular endothelial growth factor receptor-2.
Mamluk R, Carvajal IM, Morse BA, Wong H, Abramowitz J, Aslanian S, Lim AC, Gokemeijer J, Storek MJ, Lee J, Gosselin M, Wright MC, Camphausen RT, Wang J, Chen Y, Miller K, Sanders K, Short S, Sperinde J, Prasad G, Williams S, Kerbel R, Ebos J, Mutsaers A, Mendlein JD, Harris AS, Furfine ES. Mamluk R, et al. Among authors: wright mc. MAbs. 2010 Mar-Apr;2(2):199-208. doi: 10.4161/mabs.2.2.11304. MAbs. 2010. PMID: 20190562 Free PMC article.
Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression.
Donnelly DJ, Smith RA, Morin P, Lipovšek D, Gokemeijer J, Cohen D, Lafont V, Tran T, Cole EL, Wright M, Kim J, Pena A, Kukral D, Dischino DD, Chow P, Gan J, Adelakun O, Wang XT, Cao K, Leung D, Bonacorsi SJ Jr, Hayes W. Donnelly DJ, et al. J Nucl Med. 2018 Mar;59(3):529-535. doi: 10.2967/jnumed.117.199596. Epub 2017 Oct 12. J Nucl Med. 2018. PMID: 29025984 Free article.
Adnectin-drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors.
Lipovšek D, Carvajal I, Allentoff AJ, Barros A Jr, Brailsford J, Cong Q, Cotter P, Gangwar S, Hollander C, Lafont V, Lau WL, Li W, Moreta M, O'Neil S, Pinckney J, Smith MJ, Su J, Terragni C, Wallace MA, Wang L, Wright M, Marsh HN, Bryson JW. Lipovšek D, et al. Protein Eng Des Sel. 2018 May 1;31(5):159-171. doi: 10.1093/protein/gzy013. Protein Eng Des Sel. 2018. PMID: 30247737 Free PMC article.
PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury.
Michel-Flutot P, Cheng L, Thomas SJ, Lisi B, Schwartz H, Lam S, Lyttle M, Jaffe DA, Smith G, Li S, Wright MC, Lepore AC. Michel-Flutot P, et al. Among authors: wright mc. Exp Neurol. 2024 May 22;378:114816. doi: 10.1016/j.expneurol.2024.114816. Online ahead of print. Exp Neurol. 2024. PMID: 38789023
Undifferentiated HepaRG cells show reduced sensitivity to the toxic effects of M8OI through a combination of CYP3A7-mediated oxidation and a reduced reliance on mitochondrial function.
Abdelghany TM, Hedya SA, Charlton A, Aljehani FA, Alanazi K, Budastour AA, Marin L, Wright MC. Abdelghany TM, et al. Among authors: wright mc. Food Chem Toxicol. 2024 Jun;188:114681. doi: 10.1016/j.fct.2024.114681. Epub 2024 Apr 25. Food Chem Toxicol. 2024. PMID: 38677401 Free article.
A pilot study of longitudinal changes in neurocognition, white matter hyperintensities, and cortical thickness in atrial fibrillation patients following catheter ablation vs medical management.
Schwennesen H, Browndyke JN, Wright MC, Fudim M, Daubert JP, Newman MF, Mathew JP, Piccini JP. Schwennesen H, et al. Among authors: wright mc. Heart Rhythm O2. 2024 Jan 10;5(2):122-130. doi: 10.1016/j.hroo.2024.01.002. eCollection 2024 Feb. Heart Rhythm O2. 2024. PMID: 38545323 Free PMC article.
223 results