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Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
Mujib S, Jones RB, Lo C, Aidarus N, Clayton K, Sakhdari A, Benko E, Kovacs C, Ostrowski MA. Mujib S, et al. Among authors: kovacs c. J Immunol. 2012 Apr 15;188(8):3745-56. doi: 10.4049/jimmunol.1102609. Epub 2012 Mar 14. J Immunol. 2012. PMID: 22422881
Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cell immunity to gag in HIV-1-infected individuals with differential disease progression: reciprocal interferon-gamma and interleukin-10 responses.
Ostrowski MA, Gu JX, Kovacs C, Freedman J, Luscher MA, MacDonald KS. Ostrowski MA, et al. Among authors: kovacs c. J Infect Dis. 2001 Nov 15;184(10):1268-78. doi: 10.1086/324005. Epub 2001 Oct 15. J Infect Dis. 2001. PMID: 11679915
Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected individuals.
Yu Q, Gu JX, Kovacs C, Freedman J, Thomas EK, Ostrowski MA. Yu Q, et al. Among authors: kovacs c. J Immunol. 2003 Feb 15;170(4):1797-805. doi: 10.4049/jimmunol.170.4.1797. J Immunol. 2003. PMID: 12574344
Distinct transcriptional profiles in ex vivo CD4+ and CD8+ T cells are established early in human immunodeficiency virus type 1 infection and are characterized by a chronic interferon response as well as extensive transcriptional changes in CD8+ T cells.
Hyrcza MD, Kovacs C, Loutfy M, Halpenny R, Heisler L, Yang S, Wilkins O, Ostrowski M, Der SD. Hyrcza MD, et al. Among authors: kovacs c. J Virol. 2007 Apr;81(7):3477-86. doi: 10.1128/JVI.01552-06. Epub 2007 Jan 24. J Virol. 2007. PMID: 17251300 Free PMC article.
HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection.
Vali B, Yue FY, Jones RB, Sheth PM, Kaul R, Betts MR, Wong D, Kovacs C, Loutfy M, Common A, Halpenny R, Ostrowski MA. Vali B, et al. Among authors: kovacs c. PLoS One. 2008;3(10):e3454. doi: 10.1371/journal.pone.0003454. Epub 2008 Oct 20. PLoS One. 2008. PMID: 18941622 Free PMC article.
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.
Jones RB, Ndhlovu LC, Barbour JD, Sheth PM, Jha AR, Long BR, Wong JC, Satkunarajah M, Schweneker M, Chapman JM, Gyenes G, Vali B, Hyrcza MD, Yue FY, Kovacs C, Sassi A, Loutfy M, Halpenny R, Persad D, Spotts G, Hecht FM, Chun TW, McCune JM, Kaul R, Rini JM, Nixon DF, Ostrowski MA. Jones RB, et al. Among authors: kovacs c. J Exp Med. 2008 Nov 24;205(12):2763-79. doi: 10.1084/jem.20081398. Epub 2008 Nov 10. J Exp Med. 2008. PMID: 19001139 Free PMC article.
Immune reconstitution in the sigmoid colon after long-term HIV therapy.
Sheth PM, Chege D, Shin LY, Huibner S, Yue FY, Loutfy M, Halpenny R, Persad D, Kovacs C, Chun TW, Kandel G, Ostrowski M, Kaul R. Sheth PM, et al. Among authors: kovacs c. Mucosal Immunol. 2008 Sep;1(5):382-8. doi: 10.1038/mi.2008.23. Epub 2008 Jul 2. Mucosal Immunol. 2008. PMID: 19079202 Free article.
507 results