Helleday T - Search Results

1

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.

Ying S, Hamdy FC, Helleday T. Ying S, et al. Among authors: helleday t. Cancer Res. 2012 Jun 1;72(11):2814-21. doi: 10.1158/0008-5472.CAN-11-3417. Epub 2012 Mar 23. Cancer Res. 2012. PMID: 22447567

2

Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells.

Bryant HE, Ying S, Helleday T. Bryant HE, et al. Among authors: helleday t. Mutat Res. 2006 Jul 25;599(1-2):116-23. doi: 10.1016/j.mrfmmm.2006.02.001. Epub 2006 Mar 27. Mutat Res. 2006. PMID: 16564059

3

Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.

Rodriguez R, Hansen LT, Phear G, Scorah J, Spang-Thomsen M, Cox A, Helleday T, Meuth M. Rodriguez R, et al. Among authors: helleday t. Clin Cancer Res. 2008 Sep 1;14(17):5476-83. doi: 10.1158/1078-0432.CCR-08-0274. Clin Cancer Res. 2008. PMID: 18765539

4

BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells.

Ying S, Myers K, Bottomley S, Helleday T, Bryant HE. Ying S, et al. Among authors: helleday t. Nucleic Acids Res. 2009 Aug;37(15):5105-13. doi: 10.1093/nar/gkp538. Epub 2009 Jun 23. Nucleic Acids Res. 2009. PMID: 19553191 Free PMC article.

5

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Petermann E, Orta ML, Issaeva N, Schultz N, Helleday T. Petermann E, et al. Among authors: helleday t. Mol Cell. 2010 Feb 26;37(4):492-502. doi: 10.1016/j.molcel.2010.01.021. Mol Cell. 2010. PMID: 20188668 Free PMC article.

6

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.

Higgins GS, Prevo R, Lee YF, Helleday T, Muschel RJ, Taylor S, Yoshimura M, Hickson ID, Bernhard EJ, McKenna WG. Higgins GS, et al. Among authors: helleday t. Cancer Res. 2010 Apr 1;70(7):2984-93. doi: 10.1158/0008-5472.CAN-09-4040. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233878 Free PMC article.

7

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T. Gottipati P, et al. Among authors: helleday t. Cancer Res. 2010 Jul 1;70(13):5389-98. doi: 10.1158/0008-5472.CAN-09-4716. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551068 Free article.

8

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.

Issaeva N, Thomas HD, Djureinovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T. Issaeva N, et al. Among authors: helleday t. Cancer Res. 2010 Aug 1;70(15):6268-76. doi: 10.1158/0008-5472.CAN-09-3416. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631063 Free PMC article.

9

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.

Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. Chan N, et al. Among authors: helleday t. Cancer Res. 2010 Oct 15;70(20):8045-54. doi: 10.1158/0008-5472.CAN-10-2352. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924112 Free PMC article.

10

The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings.

Helleday T. Helleday T. Mol Oncol. 2011 Aug;5(4):387-93. doi: 10.1016/j.molonc.2011.07.001. Epub 2011 Jul 22. Mol Oncol. 2011. PMID: 21821475 Free PMC article. Review.

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