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Depletion of TBC1D4 improves the metabolic exercise response by overcoming genetically induced peripheral insulin resistance.
Springer C, Binsch C, Weide D, Toska L, Cremer AL, Backes H, Scheel AK, Espelage L, Kotzka J, Sill S, Kurowski A, Kim D, Karpinski S, Schnurr TM, Hansen T, Hartwig S, Lehr S, Cames S, Brüning J, Lienhard M, Herwig R, Börno S, Timmermann B, Al-Hasani H, Chadt A. Springer C, et al. Among authors: backes h. Diabetes. 2024 Apr 12:db230463. doi: 10.2337/db23-0463. Online ahead of print. Diabetes. 2024. PMID: 38608276
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.
De Solis AJ, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder CA, Eggersmann FR, Morgan DA, Cremer AL, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning JC. De Solis AJ, et al. Among authors: backes h. Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20. Nat Metab. 2024. PMID: 38378998 Free PMC article.
Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion.
Binsch C, Barbosa DM, Hansen-Dille G, Hubert M, Hodge SM, Kolasa M, Jeruschke K, Weiß J, Springer C, Gorressen S, Fischer JW, Lienhard M, Herwig R, Börno S, Timmermann B, Cremer AL, Backes H, Chadt A, Al-Hasani H. Binsch C, et al. Among authors: backes h. Cardiovasc Diabetol. 2023 Jan 27;22(1):17. doi: 10.1186/s12933-023-01746-2. Cardiovasc Diabetol. 2023. PMID: 36707786 Free PMC article.
65 results