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The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.
Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PØ, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. Willingham SB, et al. Among authors: adorno m. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6662-7. doi: 10.1073/pnas.1121623109. Epub 2012 Mar 26. Proc Natl Acad Sci U S A. 2012. PMID: 22451913 Free PMC article.
Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.
Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, Wen S, Chang YF, Bachmann MH, Shimono Y, Dalerba P, Adorno M, Lobo N, Bueno J, Dirbas FM, Goswami S, Somlo G, Condeelis J, Contag CH, Gambhir SS, Clarke MF. Liu H, et al. Among authors: adorno m. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18115-20. doi: 10.1073/pnas.1006732107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921380 Free PMC article.
Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Adorno M, Sikandar S, Mitra SS, Kuo A, Nicolis Di Robilant B, Haro-Acosta V, Ouadah Y, Quarta M, Rodriguez J, Qian D, Reddy VM, Cheshier S, Garner CC, Clarke MF. Adorno M, et al. Nature. 2013 Sep 19;501(7467):380-4. doi: 10.1038/nature12530. Epub 2013 Sep 11. Nature. 2013. PMID: 24025767 Free PMC article.
LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis.
Zabala M, Lobo NA, Antony J, Heitink LS, Gulati GS, Lam J, Parashurama N, Sanchez K, Adorno M, Sikandar SS, Kuo AH, Qian D, Kalisky T, Sim S, Li L, Dirbas FM, Somlo G, Newman A, Quake SR, Clarke MF. Zabala M, et al. Among authors: adorno m. Cell Stem Cell. 2020 Aug 6;27(2):284-299.e8. doi: 10.1016/j.stem.2020.06.017. Epub 2020 Jul 20. Cell Stem Cell. 2020. PMID: 32693087 Free article.
Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model.
Reinitz F, Chen EY, Nicolis di Robilant B, Chuluun B, Antony J, Jones RC, Gubbi N, Lee K, Ho WHD, Kolluru SS, Qian D, Adorno M, Piltti K, Anderson A, Monje M, Heller HC, Quake SR, Clarke MF. Reinitz F, et al. Among authors: adorno m. Elife. 2022 Mar 21;11:e66037. doi: 10.7554/eLife.66037. Elife. 2022. PMID: 35311644 Free PMC article.
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis.
Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S. Adorno M, et al. Cell. 2009 Apr 3;137(1):87-98. doi: 10.1016/j.cell.2009.01.039. Cell. 2009. PMID: 19345189 Free article.
46 results