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MCM: one ring to rule them all.
Deegan TD, Diffley JF. Deegan TD, et al. Curr Opin Struct Biol. 2016 Apr;37:145-51. doi: 10.1016/j.sbi.2016.01.014. Epub 2016 Feb 8. Curr Opin Struct Biol. 2016. PMID: 26866665 Review.
A conserved mechanism for regulating replisome disassembly in eukaryotes.
Jenkyn-Bedford M, Jones ML, Baris Y, Labib KPM, Cannone G, Yeeles JTP, Deegan TD. Jenkyn-Bedford M, et al. Among authors: deegan td. Nature. 2021 Dec;600(7890):743-747. doi: 10.1038/s41586-021-04145-3. Epub 2021 Oct 26. Nature. 2021. PMID: 34700328 Free PMC article.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Milligan JC, Zeisner TU, Papageorgiou G, Joshi D, Soudy C, Ulferts R, Wu M, Lim CT, Tan KW, Weissmann F, Canal B, Fujisawa R, Deegan T, Nagaraj H, Bineva-Todd G, Basier C, Curran JF, Howell M, Beale R, Labib K, O'Reilly N, Diffley JFX. Milligan JC, et al. Biochem J. 2021 Jul 16;478(13):2499-2515. doi: 10.1042/BCJ20210197. Biochem J. 2021. PMID: 34198327 Free PMC article.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase.
Basu S, Mak T, Ulferts R, Wu M, Deegan T, Fujisawa R, Tan KW, Lim CT, Basier C, Canal B, Curran JF, Drury LS, McClure AW, Roberts EL, Weissmann F, Zeisner TU, Beale R, Cowling VH, Howell M, Labib K, Diffley JFX. Basu S, et al. Biochem J. 2021 Jul 16;478(13):2481-2497. doi: 10.1042/BCJ20210219. Biochem J. 2021. PMID: 34198328 Free PMC article.
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease.
Canal B, McClure AW, Curran JF, Wu M, Ulferts R, Weissmann F, Zeng J, Bertolin AP, Milligan JC, Basu S, Drury LS, Deegan TD, Fujisawa R, Roberts EL, Basier C, Labib K, Beale R, Howell M, Diffley JFX. Canal B, et al. Among authors: deegan td. Biochem J. 2021 Jul 16;478(13):2445-2464. doi: 10.1042/BCJ20210198. Biochem J. 2021. PMID: 34198326 Free PMC article.
15 results