Havens CG - Search Results

1

Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

Salguero I, Guarino E, Shepherd ME, Deegan TD, Havens CG, MacNeill SA, Walter JC, Kearsey SE. Salguero I, et al. Among authors: havens cg. Curr Biol. 2012 Apr 24;22(8):720-6. doi: 10.1016/j.cub.2012.02.070. Epub 2012 Mar 29. Curr Biol. 2012. PMID: 22464192 Free PMC article.

2

Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

Havens CG, Walter JC. Havens CG, et al. Genes Dev. 2011 Aug 1;25(15):1568-82. doi: 10.1101/gad.2068611. Genes Dev. 2011. PMID: 21828267 Free PMC article. Review.

3

Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC. Havens CG, et al. J Biol Chem. 2012 Mar 30;287(14):11410-21. doi: 10.1074/jbc.M111.337683. Epub 2012 Feb 2. J Biol Chem. 2012. PMID: 22303007 Free PMC article.

4

Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.

Havens CG, Walter JC. Havens CG, et al. Mol Cell. 2009 Jul 10;35(1):93-104. doi: 10.1016/j.molcel.2009.05.012. Mol Cell. 2009. PMID: 19595719 Free PMC article.

5

A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.

Raman M, Havens CG, Walter JC, Harper JW. Raman M, et al. Among authors: havens cg. Mol Cell. 2011 Oct 7;44(1):72-84. doi: 10.1016/j.molcel.2011.06.036. Mol Cell. 2011. PMID: 21981919 Free PMC article.

6

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.

Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. Centore RC, et al. Among authors: havens cg. Mol Cell. 2010 Oct 8;40(1):22-33. doi: 10.1016/j.molcel.2010.09.015. Mol Cell. 2010. PMID: 20932472 Free PMC article.

7

Thymine DNA glycosylase is a CRL4Cdt2 substrate.

Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC. Slenn TJ, et al. Among authors: havens cg. J Biol Chem. 2014 Aug 15;289(33):23043-23055. doi: 10.1074/jbc.M114.574194. Epub 2014 Jun 19. J Biol Chem. 2014. PMID: 24947512 Free PMC article.

8

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

Gandhi AK, Kang J, Havens CG, Conklin T, Ning Y, Wu L, Ito T, Ando H, Waldman MF, Thakurta A, Klippel A, Handa H, Daniel TO, Schafer PH, Chopra R. Gandhi AK, et al. Among authors: havens cg. Br J Haematol. 2014 Mar;164(6):811-21. doi: 10.1111/bjh.12708. Epub 2013 Dec 13. Br J Haematol. 2014. PMID: 24328678 Free PMC article.

9

Regulation of late G1/S phase transition and APC Cdh1 by reactive oxygen species.

Havens CG, Ho A, Yoshioka N, Dowdy SF. Havens CG, et al. Mol Cell Biol. 2006 Jun;26(12):4701-11. doi: 10.1128/MCB.00303-06. Mol Cell Biol. 2006. PMID: 16738333 Free PMC article.

10

Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.

Bjorklund CC, Lu L, Kang J, Hagner PR, Havens CG, Amatangelo M, Wang M, Ren Y, Couto S, Breider M, Ning Y, Gandhi AK, Daniel TO, Chopra R, Klippel A, Thakurta AG. Bjorklund CC, et al. Among authors: havens cg. Blood Cancer J. 2015 Oct 2;5(10):e354. doi: 10.1038/bcj.2015.66. Blood Cancer J. 2015. PMID: 26430725 Free PMC article.

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