Chapman R - Search Results

1

Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).

Biju P, Wang H, Anthes J, McCormick K, Aslanian R, Berlin M, Bitar R, Lim YH, Lee YJ, Prelusky D, Mcleod R, Jia Y, Fernandez X, Lieber G, Jimenez J, Eckel S, House A, Chapman R, Phillips J. Biju P, et al. Among authors: chapman r. Bioorg Med Chem Lett. 2012 May 1;22(9):3291-5. doi: 10.1016/j.bmcl.2012.03.015. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22465636

2

Steroidal C-21 mercapto derivatives as dissociated steroids: discovery of an inhaled dissociated steroid.

Biju P, McCormick K, Aslanian R, Berlin M, Solomon D, Chapman R, McLeod R, Prelusky D, Eckel S, Kelly G, Natiello M, House A, Fernandez X, Bitar R, Phillips J, Anthes J. Biju P, et al. Among authors: chapman r. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6343-7. doi: 10.1016/j.bmcl.2011.08.108. Epub 2011 Aug 31. Bioorg Med Chem Lett. 2011. PMID: 21944381

3

Steroidal C-21 heteroaryl thioethers (Part 2): discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids).

Biju P, McCormick K, Aslanian R, Berlin M, Solomon D, Wang H, Lee YJ, Bitar R, Prelusky D, McLeod R, Jia Y, Fernandez X, Eckel S, House A, Lieber G, Jimenez J, Kelly G, Chapman R, Phillips J, Anthes J. Biju P, et al. Among authors: chapman r. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1086-90. doi: 10.1016/j.bmcl.2011.11.120. Epub 2011 Dec 7. Bioorg Med Chem Lett. 2012. PMID: 22197391

4

Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.

Ting PC, Lee JF, Shih NY, Piwinski JJ, Anthes JC, Chapman RW, Rizzo CA, Hey JA, Ng K, Nomeir AA. Ting PC, et al. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2125-8. doi: 10.1016/s0960-894x(02)00340-2. Bioorg Med Chem Lett. 2002. PMID: 12127519

5

Discovery of oral and inhaled PDE4 inhibitors.

Ting PC, Lee JF, Kuang R, Cao J, Gu D, Huang Y, Liu Z, Aslanian RG, Feng KI, Prelusky D, Lamca J, House A, Phillips JE, Wang P, Wu P, Lundell D, Chapman RW, Celly CS. Ting PC, et al. Among authors: chapman rw. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5528-32. doi: 10.1016/j.bmcl.2013.08.056. Epub 2013 Aug 21. Bioorg Med Chem Lett. 2013. PMID: 24018187

6

Effect of mometasone furoate (MF)/formoterol fumarate (F) combination (MF/F) on late-phase responses in allergen-challenged Brown Norway rats.

Chapman RW, Curran AK, House A, Richard J, Salisbury B, Hunter JC, Anthes JC, Phillips JE. Chapman RW, et al. Pulm Pharmacol Ther. 2011 Feb;24(1):67-73. doi: 10.1016/j.pupt.2010.10.002. Epub 2010 Oct 13. Pulm Pharmacol Ther. 2011. PMID: 20937404

7

Development and potential utility of dual and triple NK receptor antagonists.

Rizzo CA, Anthes JC, Corboz MR, Chapman RW, Shih NY, Reichard GA, Ng KJ, Hey JA. Rizzo CA, et al. Among authors: chapman rw. Curr Top Med Chem. 2003;3(12):1410-22. doi: 10.2174/1568026033451844. Curr Top Med Chem. 2003. PMID: 12871172 Review.

8

Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration.

Chapman RW, House A, Richard J, Prelusky D, Lamca J, Wang P, Lundell D, Wu P, Ting PC, Lee JF, Aslanian R, Phillips JE. Chapman RW, et al. Eur J Pharmacol. 2010 Sep 25;643(2-3):274-81. doi: 10.1016/j.ejphar.2010.06.054. Epub 2010 Jul 13. Eur J Pharmacol. 2010. PMID: 20621091

9

Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats.

Chapman RW, House A, Jones H, Richard J, Celly C, Prelusky D, Ting P, Hunter JC, Lamca J, Phillips JE. Chapman RW, et al. Eur J Pharmacol. 2007 Oct 1;571(2-3):215-21. doi: 10.1016/j.ejphar.2007.05.074. Epub 2007 Jun 16. Eur J Pharmacol. 2007. PMID: 17610865

10

Pharmacological characterization of the late phase reduction in lung functions and correlations with microvascular leakage and lung edema in allergen-challenged Brown Norway rats.

Mauser PJ, House A, Jones H, Correll C, Boyce C, Chapman RW. Mauser PJ, et al. Pulm Pharmacol Ther. 2013 Dec;26(6):677-84. doi: 10.1016/j.pupt.2013.03.005. Epub 2013 Mar 19. Pulm Pharmacol Ther. 2013. PMID: 23523662

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