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Steroidal C-21 heteroaryl thioethers. Part 3: pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids).
Biju P, Wang H, Anthes J, McCormick K, Aslanian R, Berlin M, Bitar R, Lim YH, Lee YJ, Prelusky D, Mcleod R, Jia Y, Fernandez X, Lieber G, Jimenez J, Eckel S, House A, Chapman R, Phillips J. Biju P, et al. Among authors: jia y. Bioorg Med Chem Lett. 2012 May 1;22(9):3291-5. doi: 10.1016/j.bmcl.2012.03.015. Epub 2012 Mar 11. Bioorg Med Chem Lett. 2012. PMID: 22465636
Steroidal C-21 heteroaryl thioethers (Part 2): discovery of orally bioavailable selective glucocorticoid receptor modulators (dissociated steroids).
Biju P, McCormick K, Aslanian R, Berlin M, Solomon D, Wang H, Lee YJ, Bitar R, Prelusky D, McLeod R, Jia Y, Fernandez X, Eckel S, House A, Lieber G, Jimenez J, Kelly G, Chapman R, Phillips J, Anthes J. Biju P, et al. Among authors: jia y. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1086-90. doi: 10.1016/j.bmcl.2011.11.120. Epub 2011 Dec 7. Bioorg Med Chem Lett. 2012. PMID: 22197391
Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
Corboz MR, Rivelli MA, McCormick KD, Wan Y, Shah H, Umland S, Lieber G, Jia Y, McLeod RL, Morgan C, Varty GB, Wu J, Feng KI, Boyce CW, Aslanian RG, Palamanda J, Nomeir AA, Korfmacher W, Hunter JC, Anthes JC, Hey JA. Corboz MR, et al. Among authors: jia y. J Pharmacol Exp Ther. 2011 Apr;337(1):256-66. doi: 10.1124/jpet.110.175794. Epub 2011 Jan 13. J Pharmacol Exp Ther. 2011. PMID: 21233198
TRPV1 antagonists as potential antitussive agents.
McLeod RL, Correll CC, Jia Y, Anthes JC. McLeod RL, et al. Among authors: jia y. Lung. 2008;186 Suppl 1:S59-65. doi: 10.1007/s00408-007-9032-z. Epub 2007 Oct 10. Lung. 2008. PMID: 17926096 Review.
Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.
Lieber GB, Fernandez X, Mingo GG, Jia Y, Caniga M, Gil MA, Keshwani S, Woodhouse JD, Cicmil M, Moy LY, Kelly N, Jimenez J, Crawley Y, Anthes JC, Klappenbach J, Ma YL, McLeod RL. Lieber GB, et al. Among authors: jia y. Eur J Pharmacol. 2013 Oct 15;718(1-3):290-8. doi: 10.1016/j.ejphar.2013.08.019. Epub 2013 Sep 5. Eur J Pharmacol. 2013. PMID: 24012780
Treatment of acute lung injury by targeting MG53-mediated cell membrane repair.
Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, Wang Z, Yao Y, Li Y, Whitson BA, Duann P, Li H, Zhou X, Zhu H, Takeshima H, Hunter JC, McLeod RL, Weisleder N, Zeng C, Ma J. Jia Y, et al. Nat Commun. 2014 Jul 18;5:4387. doi: 10.1038/ncomms5387. Nat Commun. 2014. PMID: 25034454 Free PMC article.
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