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Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage.
Amat JAR, Patton V, Chauché C, Goldfarb D, Crispell J, Gu Q, Coburn AM, Gonzalez G, Mair D, Tong L, Martinez-Sobrido L, Marshall JF, Marchesi F, Murcia PR. Amat JAR, et al. Among authors: coburn am. PLoS Pathog. 2021 Dec 17;17(12):e1010174. doi: 10.1371/journal.ppat.1010174. eCollection 2021 Dec. PLoS Pathog. 2021. PMID: 34919598 Free PMC article.
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity.
Turnbull ML, Wise HM, Nicol MQ, Smith N, Dunfee RL, Beard PM, Jagger BW, Ligertwood Y, Hardisty GR, Xiao H, Benton DJ, Coburn AM, Paulo JA, Gygi SP, McCauley JW, Taubenberger JK, Lycett SJ, Weekes MP, Dutia BM, Digard P. Turnbull ML, et al. Among authors: coburn am. J Virol. 2016 Sep 29;90(20):9263-84. doi: 10.1128/JVI.01205-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27489273 Free PMC article.
Cachexia in a B6;129S2-Tnfsf5(tm1Imx) mouse.
Coburn AM, Nicolaysen PH, Simeonova PP, Moyers WB, Battelli L, Willard P, Hubbs AF. Coburn AM, et al. Lab Anim (NY). 2004 Feb;33(2):21-3. doi: 10.1038/laban0204-21. Lab Anim (NY). 2004. PMID: 15235641 No abstract available.