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Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.
Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M. Nacerddine K, et al. Among authors: sixma tk. J Clin Invest. 2012 May;122(5):1920-32. doi: 10.1172/JCI57477. Epub 2012 Apr 16. J Clin Invest. 2012. PMID: 22505453 Free PMC article.
RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.
Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK. Mattiroli F, et al. Among authors: sixma tk. Cell. 2012 Sep 14;150(6):1182-95. doi: 10.1016/j.cell.2012.08.005. Cell. 2012. PMID: 22980979 Free article.
Histone ubiquitination in the DNA damage response.
Uckelmann M, Sixma TK. Uckelmann M, et al. Among authors: sixma tk. DNA Repair (Amst). 2017 Aug;56:92-101. doi: 10.1016/j.dnarep.2017.06.011. Epub 2017 Jun 9. DNA Repair (Amst). 2017. PMID: 28624371 Free article. Review.
Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.
Corbeski I, Guo X, Eckhardt BV, Fasci D, Wiegant W, Graewert MA, Vreeken K, Wienk H, Svergun DI, Heck AJR, van Attikum H, Boelens R, Sixma TK, Mattiroli F, van Ingen H. Corbeski I, et al. Among authors: sixma tk. Sci Adv. 2022 Jul 29;8(30):eabo0517. doi: 10.1126/sciadv.abo0517. Epub 2022 Jul 27. Sci Adv. 2022. PMID: 35895815 Free PMC article.
131 results