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Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui HC, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA; Alzheimer's Disease Genetics Consortium; Ross OA, Rademakers R, Schellenberg GD, Miller BL, Mandelkow E, Geschwind DH. Coppola G, et al. Among authors: kumar s. Hum Mol Genet. 2012 Aug 1;21(15):3500-12. doi: 10.1093/hmg/dds161. Epub 2012 May 3. Hum Mol Genet. 2012. PMID: 22556362 Free PMC article.
Oligomer formation of tau protein hyperphosphorylated in cells.
Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, Redecke L, Mandelkow EM, Müller DJ, Mandelkow E. Tepper K, et al. Among authors: kumar s. J Biol Chem. 2014 Dec 5;289(49):34389-407. doi: 10.1074/jbc.M114.611368. Epub 2014 Oct 22. J Biol Chem. 2014. PMID: 25339173 Free PMC article.
Tau protein diffuses along the microtubule lattice.
Hinrichs MH, Jalal A, Brenner B, Mandelkow E, Kumar S, Scholz T. Hinrichs MH, et al. Among authors: kumar s. J Biol Chem. 2012 Nov 9;287(46):38559-68. doi: 10.1074/jbc.M112.369785. Epub 2012 Sep 27. J Biol Chem. 2012. PMID: 23019339 Free PMC article.
The Hammersmith Infant Neurological Exam Scoring Aid supports early detection for infants with high probability of cerebral palsy.
Fehlings D, Makino A, Church P, Banihani R, Thomas K, Luther M, Lam-Damji S, Vollmer B, Haataja L, Cowan F, Romeo D, George J, Kumar S. Fehlings D, et al. Among authors: kumar s. Dev Med Child Neurol. 2024 May 31. doi: 10.1111/dmcn.15977. Online ahead of print. Dev Med Child Neurol. 2024. PMID: 38818710 No abstract available.
Concerns on H5N1 avian influenza given the outbreak in U.S. dairy cattle.
Sah R, Srivastava S, Kumar S, Mehta R, Donovan S, Sierra-Carrero L, Luna C, Woc-Colburn L, Cardona-Ospina JA, Hinestroza-Jordan M, Wessolossky M, Rodriguez-Morales AJ. Sah R, et al. Among authors: kumar s. Lancet Reg Health Am. 2024 May 23;35:100785. doi: 10.1016/j.lana.2024.100785. eCollection 2024 Jul. Lancet Reg Health Am. 2024. PMID: 38818112 Free PMC article. No abstract available.
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