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Use of libraries to access new chemical space: applications to CRTH2.
Bioorg Med Chem Lett. 2012 Jun 1;22(11):3682-7. doi: 10.1016/j.bmcl.2012.04.041. Epub 2012 Apr 20.
Bioorg Med Chem Lett. 2012.
PMID: 22560471
Staphylococcus aureus haem biosynthesis: characterisation of the enzymes involved in final steps of the pathway.
Lobo SA, Scott A, Videira MA, Winpenny D, Gardner M, Palmer MJ, Schroeder S, Lawrence AD, Parkinson T, Warren MJ, Saraiva LM.
Lobo SA, et al. Among authors: winpenny d.
Mol Microbiol. 2015 Aug;97(3):472-87. doi: 10.1111/mmi.13041. Epub 2015 May 26.
Mol Microbiol. 2015.
PMID: 25908396
Free article.
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Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode.
Boffey HK, Rooney TPC, Willems HMG, Edwards S, Green C, Howard T, Ogg D, Romero T, Scott DE, Winpenny D, Duce J, Skidmore J, Clarke JH, Andrews SP.
Boffey HK, et al. Among authors: winpenny d.
J Med Chem. 2022 Feb 24;65(4):3359-3370. doi: 10.1021/acs.jmedchem.1c01819. Epub 2022 Feb 11.
J Med Chem. 2022.
PMID: 35148092
Free PMC article.
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Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists.
Winpenny D, Clark M, Cawkill D.
Winpenny D, et al.
Br J Pharmacol. 2016 Apr;173(8):1393-403. doi: 10.1111/bph.13441. Epub 2016 Mar 1.
Br J Pharmacol. 2016.
PMID: 26791140
Free PMC article.
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The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist.
Gardiner JC, Kirkup AJ, Curry J, Humphreys S, O'Regan P, Postlethwaite M, Young KC, Kitching L, Ethell BT, Winpenny D, McMurray G.
Gardiner JC, et al. Among authors: winpenny d.
Eur J Pharmacol. 2014 Oct 5;740:398-409. doi: 10.1016/j.ejphar.2014.07.022. Epub 2014 Jul 21.
Eur J Pharmacol. 2014.
PMID: 25058909
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The rational design of ARUK2007145, a dual inhibitor of the α and γ isoforms of the lipid kinase phosphatidylinositol 5-phosphate 4-kinase (PI5P4K).
Aldred GG, Rooney TPC, Willems HMG, Boffey HK, Green C, Winpenny D, Skidmore J, Clarke JH, Andrews SP.
Aldred GG, et al. Among authors: winpenny d.
RSC Med Chem. 2023 Aug 23;14(10):2035-2047. doi: 10.1039/d3md00355h. eCollection 2023 Oct 18.
RSC Med Chem. 2023.
PMID: 37859710
Free PMC article.
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Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor.
Willems HMG, Edwards S, Boffey HK, Chawner SJ, Green C, Romero T, Winpenny D, Skidmore J, Clarke JH, Andrews SP.
Willems HMG, et al. Among authors: winpenny d.
RSC Med Chem. 2023 Apr 17;14(5):934-946. doi: 10.1039/d3md00039g. eCollection 2023 May 25.
RSC Med Chem. 2023.
PMID: 37252102
Free PMC article.
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The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules.
Rooney TPC, Aldred GG, Boffey HK, Willems HMG, Edwards S, Chawner SJ, Scott DE, Green C, Winpenny D, Skidmore J, Clarke JH, Andrews SP.
Rooney TPC, et al. Among authors: winpenny d.
J Med Chem. 2023 Jan 12;66(1):804-821. doi: 10.1021/acs.jmedchem.2c01693. Epub 2022 Dec 14.
J Med Chem. 2023.
PMID: 36516442
Free PMC article.
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