Nielsen UB - Search Results

1

Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies.

Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD. Zhou Y, et al. Among authors: nielsen ub. Mol Cancer Ther. 2012 Jul;11(7):1467-76. doi: 10.1158/1535-7163.MCT-11-1038. Epub 2012 May 7. Mol Cancer Ther. 2012. PMID: 22564724 Free PMC article.

2

Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity.

Nielsen UB, Adams GP, Weiner LM, Marks JD. Nielsen UB, et al. Cancer Res. 2000 Nov 15;60(22):6434-40. Cancer Res. 2000. PMID: 11103810

3

Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models.

Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW. Kirpotin DB, et al. Among authors: nielsen ub. Cancer Res. 2006 Jul 1;66(13):6732-40. doi: 10.1158/0008-5472.CAN-05-4199. Cancer Res. 2006. PMID: 16818648

4

A novel assay for monitoring internalization of nanocarrier coupled antibodies.

Nielsen UB, Kirpotin DB, Pickering EM, Drummond DC, Marks JD. Nielsen UB, et al. BMC Immunol. 2006 Oct 2;7:24. doi: 10.1186/1471-2172-7-24. BMC Immunol. 2006. PMID: 17014727 Free PMC article.

5

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors.

Fitzgerald JB, Johnson BW, Baum J, Adams S, Iadevaia S, Tang J, Rimkunas V, Xu L, Kohli N, Rennard R, Razlog M, Jiao Y, Harms BD, Olivier KJ Jr, Schoeberl B, Nielsen UB, Lugovskoy AA. Fitzgerald JB, et al. Among authors: nielsen ub. Mol Cancer Ther. 2014 Feb;13(2):410-25. doi: 10.1158/1535-7163.MCT-13-0255. Epub 2013 Nov 26. Mol Cancer Ther. 2014. PMID: 24282274

6

Optimizing properties of antireceptor antibodies using kinetic computational models and experiments.

Harms BD, Kearns JD, Su SV, Kohli N, Nielsen UB, Schoeberl B. Harms BD, et al. Among authors: nielsen ub. Methods Enzymol. 2012;502:67-87. doi: 10.1016/B978-0-12-416039-2.00004-5. Methods Enzymol. 2012. PMID: 22208982

7

Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, Zhang B, Luus L, Overland R, Nguyen S, Gu J, Kohli N, Wallace M, Feldhaus MJ, Kudla AJ, Schoeberl B, Nielsen UB. McDonagh CF, et al. Among authors: nielsen ub. Mol Cancer Ther. 2012 Mar;11(3):582-93. doi: 10.1158/1535-7163.MCT-11-0820. Epub 2012 Jan 16. Mol Cancer Ther. 2012. PMID: 22248472

8

Selection of tumor-specific internalizing human antibodies from phage libraries.

Poul MA, Becerril B, Nielsen UB, Morisson P, Marks JD. Poul MA, et al. Among authors: nielsen ub. J Mol Biol. 2000 Sep 1;301(5):1149-61. doi: 10.1006/jmbi.2000.4026. J Mol Biol. 2000. PMID: 10966812

9

Biological effects of anti-ErbB2 single chain antibodies selected for internalizing function.

Neve RM, Nielsen UB, Kirpotin DB, Poul MA, Marks JD, Benz CC. Neve RM, et al. Among authors: nielsen ub. Biochem Biophys Res Commun. 2001 Jan 12;280(1):274-9. doi: 10.1006/bbrc.2000.4104. Biochem Biophys Res Commun. 2001. PMID: 11162510

10

Expression of single-chain Fv-Fc fusions in Pichia pastoris.

Powers DB, Amersdorfer P, Poul M, Nielsen UB, Shalaby MR, Adams GP, Weiner LM, Marks JD. Powers DB, et al. Among authors: nielsen ub. J Immunol Methods. 2001 May 1;251(1-2):123-35. doi: 10.1016/s0022-1759(00)00290-8. J Immunol Methods. 2001. PMID: 11292488

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