Berdeja A - Search Results

1

Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides.

Roca X, Akerman M, Gaus H, Berdeja A, Bennett CF, Krainer AR. Roca X, et al. Among authors: berdeja a. Genes Dev. 2012 May 15;26(10):1098-109. doi: 10.1101/gad.190173.112. Genes Dev. 2012. PMID: 22588721 Free PMC article.

2

Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.

Wancewicz EV, Maier MA, Siwkowski AM, Albertshofer K, Winger TM, Berdeja A, Gaus H, Vickers TA, Bennett CF, Monia BP, Griffey RH, Nulf CJ, Hu J, Corey DR, Swayze EE, Kinberger GA. Wancewicz EV, et al. Among authors: berdeja a. J Med Chem. 2010 May 27;53(10):3919-26. doi: 10.1021/jm901489k. J Med Chem. 2010. PMID: 20420385 Free PMC article.

3

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST. Lima WF, et al. J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18. J Biol Chem. 2009. PMID: 19017633 Free article.

4

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: berdeja a. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

5

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

Egli M, Pallan PS, Allerson CR, Prakash TP, Berdeja A, Yu J, Lee S, Watt A, Gaus H, Bhat B, Swayze EE, Seth PP. Egli M, et al. Among authors: berdeja a. J Am Chem Soc. 2011 Oct 19;133(41):16642-9. doi: 10.1021/ja207086x. Epub 2011 Sep 22. J Am Chem Soc. 2011. PMID: 21919455 Free PMC article.

6

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

Seth PP, Allerson CR, Berdeja A, Siwkowski A, Pallan PS, Gaus H, Prakash TP, Watt AT, Egli M, Swayze EE. Seth PP, et al. Among authors: berdeja a. J Am Chem Soc. 2010 Oct 27;132(42):14942-50. doi: 10.1021/ja105875e. J Am Chem Soc. 2010. PMID: 20886816 Free PMC article.

7

Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice.

Chappell AE, Gaus HJ, Berdeja A, Gupta R, Jo M, Prakash TP, Oestergaard M, Swayze EE, Seth PP. Chappell AE, et al. Among authors: berdeja a. Nucleic Acids Res. 2020 May 7;48(8):4382-4395. doi: 10.1093/nar/gkaa164. Nucleic Acids Res. 2020. PMID: 32182359 Free PMC article.

8

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

Seth PP, Allerson CR, Siwkowski A, Vasquez G, Berdeja A, Migawa MT, Gaus H, Prakash TP, Bhat B, Swayze EE. Seth PP, et al. Among authors: berdeja a. J Med Chem. 2010 Dec 9;53(23):8309-18. doi: 10.1021/jm101207e. Epub 2010 Nov 8. J Med Chem. 2010. PMID: 21058707

9

Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.

Prakash TP, Yu J, Shen W, De Hoyos CL, Berdeja A, Gaus H, Liang XH, Crooke ST, Seth PP. Prakash TP, et al. Among authors: berdeja a. ACS Med Chem Lett. 2021 Apr 5;12(6):922-927. doi: 10.1021/acsmedchemlett.1c00072. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141070 Free PMC article.

10

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.

Wan WB, Migawa MT, Vasquez G, Murray HM, Nichols JG, Gaus H, Berdeja A, Lee S, Hart CE, Lima WF, Swayze EE, Seth PP. Wan WB, et al. Among authors: berdeja a. Nucleic Acids Res. 2014 Dec 16;42(22):13456-68. doi: 10.1093/nar/gku1115. Epub 2014 Nov 14. Nucleic Acids Res. 2014. PMID: 25398895 Free PMC article.

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