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CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients.
Sci Transl Med. 2012 May 16;4(134):134ra62. doi: 10.1126/scitranslmed.3003330.
Sci Transl Med. 2012.
PMID: 22593175
Free PMC article.
Clinical Trial.
Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells.
Vonderheide RH, LoRusso PM, Khalil M, Gartner EM, Khaira D, Soulieres D, Dorazio P, Trosko JA, Rüter J, Mariani GL, Usari T, Domchek SM.
Vonderheide RH, et al. Among authors: trosko ja.
Clin Cancer Res. 2010 Jul 1;16(13):3485-94. doi: 10.1158/1078-0432.CCR-10-0505. Epub 2010 May 17.
Clin Cancer Res. 2010.
PMID: 20479064
Clinical Trial.
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Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors.
Vonderheide RH, Burg JM, Mick R, Trosko JA, Li D, Shaik MN, Tolcher AW, Hamid O.
Vonderheide RH, et al. Among authors: trosko ja.
Oncoimmunology. 2013 Jan 1;2(1):e23033. doi: 10.4161/onci.23033.
Oncoimmunology. 2013.
PMID: 23483678
Free PMC article.
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