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Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER. Jamshidi Y, et al. Among authors: george al. J Am Coll Cardiol. 2012 Aug 28;60(9):841-50. doi: 10.1016/j.jacc.2012.03.031. Epub 2012 Jun 6. J Am Coll Cardiol. 2012. PMID: 22682551 Free PMC article.
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.
Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, Marshall V, Shakir S, Dalageorgou C, Bevan S, Jamshidi Y, Bastiaenen R, Myerburg RJ, Schott JJ, Camm AJ, Steinbeck G, Norris K, Altman RB, Tatonetti NP, Jeffery S, Kubo M, Nakamura Y, Shen Y, George AL Jr, Roden DM. Behr ER, et al. Among authors: george al jr. PLoS One. 2013 Nov 6;8(11):e78511. doi: 10.1371/journal.pone.0078511. eCollection 2013. PLoS One. 2013. PMID: 24223155 Free PMC article.
Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.
Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL Jr, Roden DM. Weeke P, et al. Among authors: george al jr. J Am Coll Cardiol. 2014 Apr 15;63(14):1430-7. doi: 10.1016/j.jacc.2014.01.031. Epub 2014 Feb 19. J Am Coll Cardiol. 2014. PMID: 24561134 Free PMC article.
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.
Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, Zhang T, Stallmeyer B, Zumhagen S, Denjoy I, Bardai A, Van Gelder IC, Jamshidi Y, Dalageorgou C, Marshall V, Jeffery S, Shakir S, Camm AJ, Steinbeck G, Perz S, Lichtner P, Meitinger T, Peters A, Wichmann HE, Ingram C, Bradford Y, Carter S, Norris K, Ritchie MD, George AL Jr, Roden DM. Kääb S, et al. Among authors: george al jr. Circ Cardiovasc Genet. 2012 Feb 1;5(1):91-9. doi: 10.1161/CIRCGENETICS.111.960930. Epub 2011 Nov 18. Circ Cardiovasc Genet. 2012. PMID: 22100668 Free PMC article.
The genetic basis of variability in drug responses.
Roden DM, George AL Jr. Roden DM, et al. Among authors: george al jr. Nat Rev Drug Discov. 2002 Jan;1(1):37-44. doi: 10.1038/nrd705. Nat Rev Drug Discov. 2002. PMID: 12119608 Review.
A common polymorphism associated with antibiotic-induced cardiac arrhythmia.
Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL Jr, Goldstein SA. Sesti F, et al. Among authors: george al jr. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10613-8. doi: 10.1073/pnas.180223197. Proc Natl Acad Sci U S A. 2000. PMID: 10984545 Free PMC article.
442 results