Loryan I - Search Results

1

UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems.

Haslemo T, Loryan I, Ueda N, Mannheimer B, Bertilsson L, Ingelman-Sundberg M, Molden E, Eliasson E. Haslemo T, et al. Among authors: loryan i. Clin Pharmacol Ther. 2012 Aug;92(2):221-7. doi: 10.1038/clpt.2012.46. Epub 2012 Jun 20. Clin Pharmacol Ther. 2012. PMID: 22713701

2

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.

Loryan I, Lindqvist M, Johansson I, Hiratsuka M, van der Heiden I, van Schaik RH, Jakobsson J, Ingelman-Sundberg M. Loryan I, et al. Eur J Clin Pharmacol. 2012 Apr;68(4):397-406. doi: 10.1007/s00228-011-1132-2. Epub 2011 Oct 18. Eur J Clin Pharmacol. 2012. PMID: 22006347 Clinical Trial.

3

Sex difference in formation of propofol metabolites: a replication study.

Choong E, Loryan I, Lindqvist M, Nordling Å, el Bouazzaoui S, van Schaik RH, Johansson I, Jakobsson J, Ingelman-Sundberg M. Choong E, et al. Among authors: loryan i. Basic Clin Pharmacol Toxicol. 2013 Aug;113(2):126-31. doi: 10.1111/bcpt.12070. Epub 2013 May 20. Basic Clin Pharmacol Toxicol. 2013. PMID: 23527701 Free article.

4

Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis.

Andronis C, Silva JP, Lekka E, Virvilis V, Carmo H, Bampali K, Ernst M, Hu Y, Loryan I, Richard J, Carvalho F, Savić MM. Andronis C, et al. Among authors: loryan i. Arch Toxicol. 2020 Aug;94(8):2829-2845. doi: 10.1007/s00204-020-02788-1. Epub 2020 Jun 5. Arch Toxicol. 2020. PMID: 32504122 Free PMC article.

5

Brain Distribution of Drugs: Pharmacokinetic Considerations.

Loryan I, Hammarlund-Udenaes M, Syvänen S. Loryan I, et al. Handb Exp Pharmacol. 2022;273:121-150. doi: 10.1007/164_2020_405. Handb Exp Pharmacol. 2022. PMID: 33258066

6

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy.

Loryan I, Melander E, Svensson M, Payan M, König F, Jansson B, Hammarlund-Udenaes M. Loryan I, et al. Mol Psychiatry. 2016 Nov;21(11):1527-1536. doi: 10.1038/mp.2015.229. Epub 2016 Jan 26. Mol Psychiatry. 2016. PMID: 26809840

7

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Luptáková D, Vallianatou T, Nilsson A, Shariatgorji R, Hammarlund-Udenaes M, Loryan I, Andrén PE. Luptáková D, et al. Among authors: loryan i. Mol Psychiatry. 2021 Dec;26(12):7732-7745. doi: 10.1038/s41380-021-01267-y. Epub 2021 Sep 3. Mol Psychiatry. 2021. PMID: 34480089 Free PMC article.

8

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates.

Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg WH, Vermeulen A, Heald D, Hammarlund-Udenaes M, Wassvik CM. Loryan I, et al. Mol Pharm. 2015 Feb 2;12(2):520-32. doi: 10.1021/mp5005965. Epub 2014 Dec 26. Mol Pharm. 2015. PMID: 25496026

9

Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development.

Loryan I, Hoppe E, Hansen K, Held F, Kless A, Linz K, Marossek V, Nolte B, Ratcliffe P, Saunders D, Terlinden R, Wegert A, Welbers A, Will O, Hammarlund-Udenaes M. Loryan I, et al. Mol Pharm. 2017 Dec 4;14(12):4362-4373. doi: 10.1021/acs.molpharmaceut.7b00480. Epub 2017 Nov 3. Mol Pharm. 2017. PMID: 29099189

10

Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies.

Yusof SR, Mohd Uzid M, Teh EH, Hanapi NA, Mohideen M, Mohamad Arshad AS, Mordi MN, Loryan I, Hammarlund-Udenaes M. Yusof SR, et al. Among authors: loryan i. Addict Biol. 2019 Sep;24(5):935-945. doi: 10.1111/adb.12661. Epub 2018 Aug 8. Addict Biol. 2019. PMID: 30088322

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