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Extensive evolutionary changes in regulatory element activity during human origins are associated with altered gene expression and positive selection.
Shibata Y, Sheffield NC, Fedrigo O, Babbitt CC, Wortham M, Tewari AK, London D, Song L, Lee BK, Iyer VR, Parker SC, Margulies EH, Wray GA, Furey TS, Crawford GE. Shibata Y, et al. Among authors: wortham m. PLoS Genet. 2012 Jun;8(6):e1002789. doi: 10.1371/journal.pgen.1002789. Epub 2012 Jun 28. PLoS Genet. 2012. PMID: 22761590 Free PMC article.
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Guo C, Chang CC, Wortham M, Chen LH, Kernagis DN, Qin X, Cho YW, Chi JT, Grant GA, McLendon RE, Yan H, Ge K, Papadopoulos N, Bigner DD, He Y. Guo C, et al. Among authors: wortham m. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17603-8. doi: 10.1073/pnas.1208807109. Epub 2012 Oct 8. Proc Natl Acad Sci U S A. 2012. PMID: 23045699 Free PMC article.
Nutrient regulation of the islet epigenome controls adaptive insulin secretion.
Wortham M, Liu F, Harrington AR, Fleischman JY, Wallace M, Mulas F, Mallick M, Vinckier NK, Cross BR, Chiou J, Patel NA, Sui Y, McGrail C, Jun Y, Wang G, Jhala US, Schüle R, Shirihai OS, Huising MO, Gaulton KJ, Metallo CM, Sander M. Wortham M, et al. J Clin Invest. 2023 Apr 17;133(8):e165208. doi: 10.1172/JCI165208. J Clin Invest. 2023. PMID: 36821378 Free PMC article.
Sizing up beta cells made from stem cells.
Nguyen-Ngoc KV, Wortham M, Sander M. Nguyen-Ngoc KV, et al. Among authors: wortham m. Nat Biotechnol. 2022 Jul;40(7):1006-1008. doi: 10.1038/s41587-022-01271-9. Nat Biotechnol. 2022. PMID: 35288669 No abstract available.
High T Gives β Cells a Boost.
Wortham M, Sander M. Wortham M, et al. Cell Metab. 2016 May 10;23(5):761-3. doi: 10.1016/j.cmet.2016.04.015. Cell Metab. 2016. PMID: 27166938 Free article.
23 results