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Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.
Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, Oo YH, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P. Billerbeck E, et al. Among authors: klenerman p. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11. doi: 10.1073/pnas.0914839107. Epub 2010 Jan 28. Proc Natl Acad Sci U S A. 2010. PMID: 20133607 Free PMC article.
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.
Walker LJ, Kang YH, Smith MO, Tharmalingham H, Ramamurthy N, Fleming VM, Sahgal N, Leslie A, Oo Y, Geremia A, Scriba TJ, Hanekom WA, Lauer GM, Lantz O, Adams DH, Powrie F, Barnes E, Klenerman P. Walker LJ, et al. Among authors: klenerman p. Blood. 2012 Jan 12;119(2):422-33. doi: 10.1182/blood-2011-05-353789. Epub 2011 Nov 15. Blood. 2012. PMID: 22086415 Free PMC article.
Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.
Barnes E, Folgori A, Capone S, Swadling L, Aston S, Kurioka A, Meyer J, Huddart R, Smith K, Townsend R, Brown A, Antrobus R, Ammendola V, Naddeo M, O'Hara G, Willberg C, Harrison A, Grazioli F, Esposito ML, Siani L, Traboni C, Oo Y, Adams D, Hill A, Colloca S, Nicosia A, Cortese R, Klenerman P. Barnes E, et al. Among authors: klenerman p. Sci Transl Med. 2012 Jan 4;4(115):115ra1. doi: 10.1126/scitranslmed.3003155. Sci Transl Med. 2012. PMID: 22218690 Free PMC article.
CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ.
Kang YH, Seigel B, Bengsch B, Fleming VM, Billerbeck E, Simmons R, Walker L, Willberg CB, Barnes EJ, Bhagwanani A, Oo YH, Blum HE, Adams DH, Thimme R, Klenerman P. Kang YH, et al. Among authors: klenerman p. Front Immunol. 2012 Nov 20;3:346. doi: 10.3389/fimmu.2012.00346. eCollection 2012. Front Immunol. 2012. PMID: 23181064 Free PMC article.
Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans.
Kelly C, Swadling L, Capone S, Brown A, Richardson R, Halliday J, von Delft A, Oo Y, Mutimer D, Kurioka A, Hartnell F, Collier J, Ammendola V, Del Sorbo M, Grazioli F, Esposito ML, Di Marco S, Siani L, Traboni C, Hill AV, Colloca S, Nicosia A, Cortese R, Folgori A, Klenerman P, Barnes E. Kelly C, et al. Among authors: klenerman p. Hepatology. 2016 May;63(5):1455-70. doi: 10.1002/hep.28294. Epub 2016 Jan 22. Hepatology. 2016. PMID: 26474390 Free PMC article.
Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.
Jeffery HC, van Wilgenburg B, Kurioka A, Parekh K, Stirling K, Roberts S, Dutton EE, Hunter S, Geh D, Braitch MK, Rajanayagam J, Iqbal T, Pinkney T, Brown R, Withers DR, Adams DH, Klenerman P, Oo YH. Jeffery HC, et al. Among authors: klenerman p. J Hepatol. 2016 May;64(5):1118-1127. doi: 10.1016/j.jhep.2015.12.017. Epub 2015 Dec 29. J Hepatol. 2016. PMID: 26743076 Free PMC article.
MAIT cells are activated during human viral infections.
van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L; STOP-HCV consortium; Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR, Klenerman P. van Wilgenburg B, et al. Among authors: klenerman p. Nat Commun. 2016 Jun 23;7:11653. doi: 10.1038/ncomms11653. Nat Commun. 2016. PMID: 27337592 Free PMC article.
Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.
Riva A, Patel V, Kurioka A, Jeffery HC, Wright G, Tarff S, Shawcross D, Ryan JM, Evans A, Azarian S, Bajaj JS, Fagan A, Patel V, Mehta K, Lopez C, Simonova M, Katzarov K, Hadzhiolova T, Pavlova S, Wendon JA, Oo YH, Klenerman P, Williams R, Chokshi S. Riva A, et al. Among authors: klenerman p. Gut. 2018 May;67(5):918-930. doi: 10.1136/gutjnl-2017-314458. Epub 2017 Nov 2. Gut. 2018. PMID: 29097439 Free PMC article.
687 results