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A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Mehrotra S, Al-Khami AA, Klarquist J, Husain S, Naga O, Eby JM, Murali AK, Lyons GE, Li M, Spivey ND, Norell H, Martins da Palma T, Onicescu G, Diaz-Montero CM, Garrett-Mayer E, Cole DJ, Le Poole IC, Nishimura MI. Mehrotra S, et al. J Immunol. 2012 Aug 15;189(4):1627-38. doi: 10.4049/jimmunol.1103271. Epub 2012 Jul 13. J Immunol. 2012. PMID: 22798675 Free PMC article.
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C).
Salem ML, Díaz-Montero CM, Al-Khami AA, El-Naggar SA, Naga O, Montero AJ, Khafagy A, Cole DJ. Salem ML, et al. J Immunol. 2009 Feb 15;182(4):2030-40. doi: 10.4049/jimmunol.0801829. J Immunol. 2009. PMID: 19201856 Free PMC article.
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model.
Díaz-Montero CM, El Naggar S, Al Khami A, El Naggar R, Montero AJ, Cole DJ, Salem ML. Díaz-Montero CM, et al. Cancer Immunol Immunother. 2008 Apr;57(4):563-72. doi: 10.1007/s00262-007-0394-0. Epub 2007 Aug 28. Cancer Immunol Immunother. 2008. PMID: 17726606 Free PMC article.
48 results