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Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Paquette N, Conlon J, Sweet C, Rus F, Wilson L, Pereira A, Rosadini CV, Goutagny N, Weber AN, Lane WS, Shaffer SA, Maniatis S, Fitzgerald KA, Stuart L, Silverman N. Paquette N, et al. Among authors: shaffer sa. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12710-5. doi: 10.1073/pnas.1008203109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802624 Free PMC article.
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.
Xie J, Peng M, Guillemette S, Quan S, Maniatis S, Wu Y, Venkatesh A, Shaffer SA, Brosh RM Jr, Cantor SB. Xie J, et al. Among authors: shaffer sa. PLoS Genet. 2012 Jul;8(7):e1002786. doi: 10.1371/journal.pgen.1002786. Epub 2012 Jul 5. PLoS Genet. 2012. PMID: 22792074 Free PMC article.
Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers.
Jones KA, Kim PD, Patel BB, Kelsen SG, Braverman A, Swinton DJ, Gafken PR, Jones LA, Lane WS, Neveu JM, Leung HE, Shaffer SA, Leszyk JD, Stanley BA, Fox TE, Stanley A, Hall MJ, Hampel H, South CD, de la Chapelle A, Burt RW, Jones DA, Kopelovich L, Yeung AT. Jones KA, et al. Among authors: shaffer sa. J Proteome Res. 2013 Oct 4;12(10):4351-65. doi: 10.1021/pr400307u. Epub 2013 Sep 19. J Proteome Res. 2013. PMID: 24004147 Free PMC article.
Succination inactivates gasdermin D and blocks pyroptosis.
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Humphries F, et al. Among authors: shaffer sa. Science. 2020 Sep 25;369(6511):1633-1637. doi: 10.1126/science.abb9818. Epub 2020 Aug 20. Science. 2020. PMID: 32820063 Free PMC article.
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Shmuel-Galia L, et al. Among authors: shaffer sa. Immunity. 2021 Jun 8;54(6):1137-1153.e8. doi: 10.1016/j.immuni.2021.05.008. Epub 2021 May 28. Immunity. 2021. PMID: 34051146 Free PMC article.
167 results