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Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy.
Alarcon SV, Mollapour M, Lee MJ, Tsutsumi S, Lee S, Kim YS, Prince T, Apolo AB, Giaccone G, Xu W, Neckers LM, Trepel JB. Alarcon SV, et al. Among authors: prince t. Curr Mol Med. 2012 Nov 1;12(9):1125-41. doi: 10.2174/156652412803306729. Curr Mol Med. 2012. PMID: 22804236 Free PMC article. Review.
Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.
Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L. Mollapour M, et al. Among authors: prince t. Mol Cell. 2014 Jan 23;53(2):317-29. doi: 10.1016/j.molcel.2013.12.007. Mol Cell. 2014. PMID: 24462205 Free PMC article.
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.
Schwartz H, Scroggins B, Zuehlke A, Kijima T, Beebe K, Mishra A, Neckers L, Prince T. Schwartz H, et al. Among authors: prince t. Cell Stress Chaperones. 2015 Sep;20(5):729-41. doi: 10.1007/s12192-015-0604-1. Epub 2015 Jun 13. Cell Stress Chaperones. 2015. PMID: 26070366 Free PMC article. Review.
Regulation and function of the human HSP90AA1 gene.
Zuehlke AD, Beebe K, Neckers L, Prince T. Zuehlke AD, et al. Among authors: prince t. Gene. 2015 Oct 1;570(1):8-16. doi: 10.1016/j.gene.2015.06.018. Epub 2015 Jun 10. Gene. 2015. PMID: 26071189 Free PMC article. Review.
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.
Sattin S, Tao J, Vettoretti G, Moroni E, Pennati M, Lopergolo A, Morelli L, Bugatti A, Zuehlke A, Moses M, Prince T, Kijima T, Beebe K, Rusnati M, Neckers L, Zaffaroni N, Agard DA, Bernardi A, Colombo G. Sattin S, et al. Among authors: prince t. Chemistry. 2015 Sep 21;21(39):13598-608. doi: 10.1002/chem.201502211. Epub 2015 Aug 18. Chemistry. 2015. PMID: 26286886 Free PMC article.
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
Prince TL, Kijima T, Tatokoro M, Lee S, Tsutsumi S, Yim K, Rivas C, Alarcon S, Schwartz H, Khamit-Kush K, Scroggins BT, Beebe K, Trepel JB, Neckers L. Prince TL, et al. PLoS One. 2015 Oct 30;10(10):e0141786. doi: 10.1371/journal.pone.0141786. eCollection 2015. PLoS One. 2015. PMID: 26517842 Free PMC article.
173 results