Zhao R - Search Results

1

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity.

Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Krueger AB, et al. Among authors: zhao r. J Biomol Screen. 2013 Jan;18(1):85-96. doi: 10.1177/1087057112453936. Epub 2012 Jul 20. J Biomol Screen. 2013. PMID: 22820394 Free PMC article.

2

Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations.

Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Patrick AN, et al. Among authors: zhao r. J Biol Chem. 2009 Jul 31;284(31):20781-90. doi: 10.1074/jbc.M109.016832. Epub 2009 Jun 4. J Biol Chem. 2009. PMID: 19497856 Free PMC article.

3

Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties.

Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL. Farabaugh SM, et al. Among authors: zhao r. Oncogene. 2012 Feb 2;31(5):552-62. doi: 10.1038/onc.2011.259. Epub 2011 Jun 27. Oncogene. 2012. PMID: 21706047 Free PMC article.

4

Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.

Li X, Zhang W, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Li X, et al. Among authors: zhao r. Nucleic Acids Res. 2013 Apr 1;41(6):3805-18. doi: 10.1093/nar/gkt062. Epub 2013 Feb 7. Nucleic Acids Res. 2013. PMID: 23393194 Free PMC article.

5

Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.

Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R. Patrick AN, et al. Among authors: zhao r. Nat Struct Mol Biol. 2013 Apr;20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24. Nat Struct Mol Biol. 2013. PMID: 23435380 Free PMC article.

6

Structural analyses of the pre-mRNA splicing machinery.

Zhang L, Li X, Zhao R. Zhang L, et al. Among authors: zhao r. Protein Sci. 2013 Jun;22(6):677-92. doi: 10.1002/pro.2266. Epub 2013 May 8. Protein Sci. 2013. PMID: 23592432 Free PMC article. Review.

7

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.

Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: zhao r. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.

8

Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression.

Blevins MA, Kouznetsova J, Krueger AB, King R, Griner LM, Hu X, Southall N, Marugan JJ, Zhang Q, Ferrer M, Zhao R. Blevins MA, et al. Among authors: zhao r. J Biomol Screen. 2015 Jun;20(5):663-72. doi: 10.1177/1087057114561400. Epub 2014 Dec 4. J Biomol Screen. 2015. PMID: 25477201 Free PMC article.

9

The SIX1-EYA transcriptional complex as a therapeutic target in cancer.

Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. Blevins MA, et al. Among authors: zhao r. Expert Opin Ther Targets. 2015 Feb;19(2):213-25. doi: 10.1517/14728222.2014.978860. Epub 2015 Jan 2. Expert Opin Ther Targets. 2015. PMID: 25555392 Free PMC article. Review.

10

Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.

Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Zhang L, et al. Among authors: zhao r. Nucleic Acids Res. 2015 Mar 31;43(6):3286-97. doi: 10.1093/nar/gkv062. Epub 2015 Feb 10. Nucleic Acids Res. 2015. PMID: 25670679 Free PMC article.

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