Ostergaard H - Search Results

1

The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells.

Carneiro-Lobo TC, Schaffner F, Disse J, Ostergaard H, Francischetti IM, Monteiro RQ, Ruf W. Carneiro-Lobo TC, et al. Among authors: ostergaard h. J Thromb Haemost. 2012 Sep;10(9):1849-58. doi: 10.1111/j.1538-7836.2012.04864.x. J Thromb Haemost. 2012. PMID: 22823596 Free PMC article.

2

Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.

Kamikubo Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale AJ, Krishnaswamy S, Gruber A, Østergaard H, Petersen LC, Ruf W, Ruggeri ZM. Kamikubo Y, et al. Among authors: ostergaard h. Blood. 2017 Oct 5;130(14):1661-1670. doi: 10.1182/blood-2017-02-767079. Epub 2017 Jul 20. Blood. 2017. PMID: 28729433 Free PMC article.

3

Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling.

Rothmeier AS, Liu E, Chakrabarty S, Disse J, Mueller BM, Østergaard H, Ruf W. Rothmeier AS, et al. Among authors: ostergaard h. Blood. 2018 Feb 8;131(6):674-685. doi: 10.1182/blood-2017-02-768218. Epub 2017 Dec 15. Blood. 2018. PMID: 29246902 Free PMC article.

4

Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa.

Zhang Q, Petersen HH, Ostergaard H, Ruf W, Olson AJ. Zhang Q, et al. Among authors: ostergaard h. Proteins. 2009 Nov 15;77(3):559-69. doi: 10.1002/prot.22468. Proteins. 2009. PMID: 19536895 Free PMC article.

5

Engineering of a membrane-triggered activity switch in coagulation factor VIIa.

Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sørensen BB, Ruf W, Olsen OH, Østergaard H. Nielsen AL, et al. Among authors: ostergaard h. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12454-12459. doi: 10.1073/pnas.1618713114. Epub 2017 Nov 6. Proc Natl Acad Sci U S A. 2017. PMID: 29109275 Free PMC article.

6

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

Larsen KS, Ostergaard H, Olsen OH, Bjelke JR, Ruf W, Petersen LC. Larsen KS, et al. Among authors: ostergaard h. J Biol Chem. 2010 Jun 25;285(26):19959-66. doi: 10.1074/jbc.M110.101030. Epub 2010 Apr 13. J Biol Chem. 2010. PMID: 20388709 Free PMC article.

7

Generation and biochemical characterization of glycoPEGylated factor VIIa derivatives.

Stennicke HR, Ostergaard H, Bayer RJ, Kalo MS, Kinealy K, Holm PK, Sørensen BB, Zopf D, Bjørn SE. Stennicke HR, et al. Among authors: ostergaard h. Thromb Haemost. 2008 Nov;100(5):920-8. Thromb Haemost. 2008. PMID: 18989539

8

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity.

Sorensen AB, Madsen JJ, Svensson LA, Pedersen AA, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Sorensen AB, et al. Among authors: ostergaard h. J Biol Chem. 2016 Feb 26;291(9):4671-83. doi: 10.1074/jbc.M115.698613. Epub 2015 Dec 22. J Biol Chem. 2016. PMID: 26694616 Free PMC article.

9

Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa.

Sorensen AB, Tuneew I, Svensson LA, Persson E, Østergaard H, Overgaard MT, Olsen OH, Gandhi PS. Sorensen AB, et al. Among authors: ostergaard h. J Biol Chem. 2020 Jan 10;295(2):517-528. doi: 10.1074/jbc.RA119.009183. Epub 2019 Dec 4. J Biol Chem. 2020. PMID: 31801825 Free PMC article.

10

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.

Olsen OH, Rand KD, Østergaard H, Persson E. Olsen OH, et al. Among authors: ostergaard h. Protein Sci. 2007 Apr;16(4):671-82. doi: 10.1110/ps.062504907. Protein Sci. 2007. PMID: 17384232 Free PMC article.

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